2-(3-(tert-butyldimethylsilyloxy)propyl)-4-(2-methoxyphenyl)piperidin-4-ol

Base Information

Chemical Name:2-(3-(tert-butyldimethylsilyloxy)propyl)-4-(2-methoxyphenyl)piperidin-4-ol
CAS No.:1292307-33-5
Molecular Formula:C₂₁H₃₇NO₃Si
Molecular Weight:379.615
Hs Code.:

Synonyms:2-(3-(tert-butyldimethylsilyloxy)propyl)-4-(2-methoxyphenyl)piperidin-4-ol

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Chemical Property of 2-(3-(tert-butyldimethylsilyloxy)propyl)-4-(2-methoxyphenyl)piperidin-4-ol

Chemical Property:

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Technology Process of 2-(3-(tert-butyldimethylsilyloxy)propyl)-4-(2-methoxyphenyl)piperidin-4-ol

There total 6 articles about 2-(3-(tert-butyldimethylsilyloxy)propyl)-4-(2-methoxyphenyl)piperidin-4-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1292307-32-4
benzyl 2-(3-(tert-butyldimethylsilyloxy)propyl)-4-hydroxy-4-(2-methoxyphenyl)piperidine-1-carboxylate

: 1292307-33-5
2-(3-(tert-butyldimethylsilyloxy)propyl)-4-(2-methoxyphenyl)piperidin-4-ol

Guidance literature:: With hydrogen; palladium-on-charcoal; In ethyl acetate; for 2h;

Reference yield:

: 620-08-6,1232006-56-2
4-methoxypyridine

: 1292307-33-5
2-(3-(tert-butyldimethylsilyloxy)propyl)-4-(2-methoxyphenyl)piperidin-4-ol

Guidance literature:: Multi-step reaction with 6 steps

1.1: diethyl ether; tetrahydrofuran / 0.5 h / -23 °C

2.1: zinc; acetic acid / 16 h / 50 °C

3.1: diethyl ether; tetrahydrofuran / 2 h / -78 °C

4.1: 9-bora-bicyclo[3.3.1]nonane / tetrahydrofuran / 16 h / 20 °C

4.2: 0.5 h

5.1: triethylamine / dmap / dichloromethane / 16 h / 0 - 20 °C

6.1: hydrogen / palladium-on-charcoal / ethyl acetate / 2 h

With hydrogen; acetic acid; triethylamine; 9-bora-bicyclo[3.3.1]nonane; zinc; dmap; palladium-on-charcoal; In tetrahydrofuran; diethyl ether; dichloromethane; ethyl acetate;

Reference yield:

: 1292307-29-9
benzyl 2-allyl-4-oxopiperidine-1-carboxylate

: 1292307-33-5
2-(3-(tert-butyldimethylsilyloxy)propyl)-4-(2-methoxyphenyl)piperidin-4-ol

Guidance literature:: Multi-step reaction with 4 steps

1.1: diethyl ether; tetrahydrofuran / 2 h / -78 °C

2.1: 9-bora-bicyclo[3.3.1]nonane / tetrahydrofuran / 16 h / 20 °C

2.2: 0.5 h

3.1: triethylamine / dmap / dichloromethane / 16 h / 0 - 20 °C

4.1: hydrogen / palladium-on-charcoal / ethyl acetate / 2 h

With hydrogen; triethylamine; 9-bora-bicyclo[3.3.1]nonane; dmap; palladium-on-charcoal; In tetrahydrofuran; diethyl ether; dichloromethane; ethyl acetate;