benzyl 2-(3-(tert-butyldimethylsilyloxy)propyl)-4-hydroxy-4-(2-methoxyphenyl)piperidine-1-carboxylate

Base Information

Chemical Name:benzyl 2-(3-(tert-butyldimethylsilyloxy)propyl)-4-hydroxy-4-(2-methoxyphenyl)piperidine-1-carboxylate
CAS No.:1292307-32-4
Molecular Formula:C₂₉H₄₃NO₅Si
Molecular Weight:513.75
Hs Code.:

Synonyms:benzyl 2-(3-(tert-butyldimethylsilyloxy)propyl)-4-hydroxy-4-(2-methoxyphenyl)piperidine-1-carboxylate

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Chemical Property of benzyl 2-(3-(tert-butyldimethylsilyloxy)propyl)-4-hydroxy-4-(2-methoxyphenyl)piperidine-1-carboxylate

Chemical Property:

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Technology Process of benzyl 2-(3-(tert-butyldimethylsilyloxy)propyl)-4-hydroxy-4-(2-methoxyphenyl)piperidine-1-carboxylate

There total 6 articles about benzyl 2-(3-(tert-butyldimethylsilyloxy)propyl)-4-hydroxy-4-(2-methoxyphenyl)piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1292307-31-3
benzyl 4-hydroxy-2-(3-hydroxypropyl)-4-(2-methoxyphenyl)piperidine-1-carboxylate

: 18162-48-6
tert-butyldimethylsilyl chloride

: 1292307-32-4
benzyl 2-(3-(tert-butyldimethylsilyloxy)propyl)-4-hydroxy-4-(2-methoxyphenyl)piperidine-1-carboxylate

Guidance literature:: With triethylamine; dmap; In dichloromethane; at 0 - 20 ℃; for 16h;

Reference yield:

: 501-53-1,94274-21-2
benzyl chloroformate

: 1292307-32-4
benzyl 2-(3-(tert-butyldimethylsilyloxy)propyl)-4-hydroxy-4-(2-methoxyphenyl)piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: diethyl ether; tetrahydrofuran / 0.5 h / -23 °C

2.1: zinc; acetic acid / 16 h / 50 °C

3.1: diethyl ether; tetrahydrofuran / 2 h / -78 °C

4.1: 9-bora-bicyclo[3.3.1]nonane / tetrahydrofuran / 16 h / 20 °C

4.2: 0.5 h

5.1: triethylamine / dmap / dichloromethane / 16 h / 0 - 20 °C

With acetic acid; triethylamine; 9-bora-bicyclo[3.3.1]nonane; zinc; dmap; In tetrahydrofuran; diethyl ether; dichloromethane;

Reference yield:

: 620-08-6,1232006-56-2
4-methoxypyridine

: 1292307-32-4
benzyl 2-(3-(tert-butyldimethylsilyloxy)propyl)-4-hydroxy-4-(2-methoxyphenyl)piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: diethyl ether; tetrahydrofuran / 0.5 h / -23 °C

2.1: zinc; acetic acid / 16 h / 50 °C

3.1: diethyl ether; tetrahydrofuran / 2 h / -78 °C

4.1: 9-bora-bicyclo[3.3.1]nonane / tetrahydrofuran / 16 h / 20 °C

4.2: 0.5 h

5.1: triethylamine / dmap / dichloromethane / 16 h / 0 - 20 °C

With acetic acid; triethylamine; 9-bora-bicyclo[3.3.1]nonane; zinc; dmap; In tetrahydrofuran; diethyl ether; dichloromethane;