794460-89-2

Basic information

• Product Name: (2S)-1-{[(1-aMino-2-Methylpropan-2-yl)aMino]acetyl}pyrrolidine-2-carbonitrile Hydrochloride
• Synonyms: (2S)-1-[[(2-AMino-1,1-diMethylethyl)aMino]acetyl]-2-pyrrolidinecarbonitrile;(S)-1-(2-((1-amino-2-methylpropan-2-yl)amino)acetyl)pyrrolidine-2-carbonitrile Hydrochloride;(S)-1-(2-((1-amino-2-methylpropan-2-yl)amino)acetyl)pyrrolidine-2-carbonitrile;(2S)-1-{[(1-aMino-2-Methylpropan-2-yl)aMino]acetyl}pyrrolidine-2-carbonitrile Hydrochloride;Anagliptin InterMediate B
• CAS NO: 794460-89-2
• Molecular Formula: C₁₁H₂₀N₄O
• Molecular Weight: 260.76364
• EINECS: -0
• Mol File: 794460-89-2.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (2S)-1-{[(1-aMino-2-Methylpropan-2-yl)aMino]acetyl}pyrrolidine-2-carbonitrile Hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: (2S)-1-{[(1-aMino-2-Methylpropan-2-yl)aMino]acetyl}pyrrolidine-2-carbonitrile Hydrochloride(794460-89-2)
• EPA Substance Registry System: (2S)-1-{[(1-aMino-2-Methylpropan-2-yl)aMino]acetyl}pyrrolidine-2-carbonitrile Hydrochloride(794460-89-2)

Safety Data

• Hazardous Substances Data: 794460-89-2(Hazardous Substances Data)

Usage

General Description

The chemical compound "(2S)-1-{[(1-aMino-2-Methylpropan-2-yl)aMino]acetyl}pyrrolidine-2-carbonitrile Hydrochloride" is a hydrochloride salt of a pyrrolidine-based compound with the molecular formula C12H21N4O. It is a synthetic compound designed for research and experimental purposes, and it is commonly used as a building block in the synthesis of pharmaceutical agents and other organic compounds. The compound's structure contains an acetyl group and a carboxamide group attached to a pyrrolidine ring, and it also contains a secondary amine and a nitrile functional group, which gives it potential biological activity. Additionally, the hydrochloride salt form enhances the compound's water solubility and stability, making it more suitable for certain applications in the laboratory and in drug development.

Upstream product

• 207557-35-5 (S)-1-(2-chloroacetyl)pyrrolidine-2-carbonitrile 
• 739365-95-8 tert-butyl N-[2-({2-[(2S)-2-cyanopyrrolidin-1-yl]-2-oxoethyl}amino)-2-methylpropyl]carbamate 

Downstream Products

• 1359670-56-6 N-[2-({2-[(2S)-2-cyanopyrrolidine-1-yl]-2-oxoethyl}amino)-2-methylpropyl]-2-methylpyrazolo[1,5-a]pyrimidine-6-carboxamide hydrochloride 
• 1359669-28-5 (S)-2-phenyl-7-methylpyrazolo[1,5-a]pyrimidine-6-carboxylic acid {2-[(2-cyanopyrrolidin-1-yl)-2-oxoethylamino]-2-methylpropyl}amide hydrochloride 
• 1359669-09-2 (S)-2-phenyl-5,7-dimethylpyrazolo[1,5-a]pyrimidine-6-carboxylic acid {2-[(2-cyanopyrrolidin-1-yl)-2-oxoethylamino]-2-methylpropyl}amide hydrochloride 
• 739366-20-2 (S)-2-methylpyrazolo[1,5-a]pyrimidine-6-carboxylic acid {2-[(2-cyanopyrrolidin-1-yl)-2-oxoethylamino]-2-methylpropyl}amide 

Relevant articles and documents

Compound 1 - (diphenyl methylene) amino-2-amino-2-methyl propane and its preparation method and application

The invention relates to a new compound 1-(diphenyl methylene) amino-2-amino-2-methylmethane, a preparation method and application thereof in Anagliptin synthesis. 1-(diphenyl methylene) amino-2-amino-2-methylmethane is a (I) compound; the Formula is a key intermediate in the Anagliptin synthesis; the intermediate is stable and easy to get, plays a vital role in synthesizing the final target compound; moreover, the method is simple in technical flow process, higher in yielding and applicable to large-scale production.

Discovery and pharmacological characterization of N-[2-({2-[(2S)-2- cyanopyrrolidin-1-yl]-2-oxoethyl}amino)-2-methylpropyl]-2-methylpyrazolo[1,5-a] pyrimidine-6-carboxamide hydrochloride (anagliptin hydrochloride salt) as a potent and selective DPP-IV inhibitor

In the course of our program for discovery of novel DPP-IV inhibitors, a series of pyrazolo[1,5-a]pyrimidines were found to be novel DPP-IV inhibitors. We identified N-[2-({2-[(2S)-2-cyanopyrrolidin-1-yl]-2-oxoethyl}amino)-2- methylpropyl]-2-methylpyrazolo[1,5-a]pyrimidine-6-carboxamide hydrochloride (4a) and described its pharmacological profiles.