2,6-di(tert-butyl)-4-methylphenyl 1-(α-hydroxybenzyl)-2-methylcyclopropanecarboxylate

Base Information

Chemical Name:2,6-di(tert-butyl)-4-methylphenyl 1-(α-hydroxybenzyl)-2-methylcyclopropanecarboxylate
CAS No.:108546-86-7
Molecular Formula:C₂₇H₃₆O₃
Molecular Weight:408.581
Hs Code.:

Synonyms:2,6-di(tert-butyl)-4-methylphenyl 1-(α-hydroxybenzyl)-2-methylcyclopropanecarboxylate

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Chemical Property of 2,6-di(tert-butyl)-4-methylphenyl 1-(α-hydroxybenzyl)-2-methylcyclopropanecarboxylate

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Technology Process of 2,6-di(tert-butyl)-4-methylphenyl 1-(α-hydroxybenzyl)-2-methylcyclopropanecarboxylate

There total 3 articles about 2,6-di(tert-butyl)-4-methylphenyl 1-(α-hydroxybenzyl)-2-methylcyclopropanecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 100-52-7
benzaldehyde

: 108546-82-3
2,6-di-t-butyl-4-methylphenyl 2-methylcyclopropanecarboxylic acid ester

: 108546-86-7
2,6-di(tert-butyl)-4-methylphenyl 1-(α-hydroxybenzyl)-2-methylcyclopropanecarboxylate

Guidance literature:: With tert.-butyl lithium; In tetrahydrofuran; at -78 ℃; for 0.0833333h; 1.) 30 min;
DOI:10.1002/hlca.19860690720

Reference yield:

: 42274-66-8,52194-64-6,52194-65-7,60733-34-8
2-methylcyclopropanecarboxylic acid chloride

: 108546-86-7
2,6-di(tert-butyl)-4-methylphenyl 1-(α-hydroxybenzyl)-2-methylcyclopropanecarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: 81 percent / 1.) BuLi in hexane / tetrahydrofuran / 24 h / Ambient temperature; 1.) 10 min

2: 84 percent / 1.) t-BuLi in pentane / tetrahydrofuran / 0.08 h / -78 °C / 1.) 30 min

With n-butyllithium; tert.-butyl lithium; In tetrahydrofuran;
DOI:10.1002/hlca.19860690720

Reference yield:

: 29555-02-0
2-methyl-cyclopropanecarboxylic acid

: 108546-86-7
2,6-di(tert-butyl)-4-methylphenyl 1-(α-hydroxybenzyl)-2-methylcyclopropanecarboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: SOCl₂

2: 81 percent / 1.) BuLi in hexane / tetrahydrofuran / 24 h / Ambient temperature; 1.) 10 min

3: 84 percent / 1.) t-BuLi in pentane / tetrahydrofuran / 0.08 h / -78 °C / 1.) 30 min

With n-butyllithium; thionyl chloride; tert.-butyl lithium; In tetrahydrofuran;
DOI:10.1002/hlca.19860690720