methyl (S)-2-[2-(dimethoxyphosphoryl)acetamido]-2-phenylacetate

Base Information

• Chemical Name: methyl (S)-2-[2-(dimethoxyphosphoryl)acetamido]-2-phenylacetate
• CAS No.: 1000619-63-5
• Molecular Formula: C₁₃H₁₈NO₆P
• Molecular Weight: 315.263
• Mol file: 1000619-63-5.mol

Synonyms:methyl (S)-2-[2-(dimethoxyphosphoryl)acetamido]-2-phenylacetate

Chemical Property of methyl (S)-2-[2-(dimethoxyphosphoryl)acetamido]-2-phenylacetate

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of methyl (S)-2-[2-(dimethoxyphosphoryl)acetamido]-2-phenylacetate

There total 1 articles about methyl (S)-2-[2-(dimethoxyphosphoryl)acetamido]-2-phenylacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

methyl (S)-2-(2-bromoacetamido)-2-phenylacetate (219886-80-3) + phosphorous acid trimethyl ester (121-45-9) → methyl (S)-2-[2-(dimethoxyphosphoryl)acetamido]-2-phenylacetate (1000619-63-5)

Guidance literature:

at 105 - 110 ℃;

DOI:10.1016/j.tetasy.2007.09.033

Reference yield: 93.0%

methyl (S)-2-[2-(dimethoxyphosphoryl)acetamido]-2-phenylacetate (1000619-63-5) → methyl (S)-(E)-N-(p-chlorocinnamoyl)-2-amino-2-phenylacetate

Guidance literature:

methyl (S)-2-[2-(dimethoxyphosphoryl)acetamido]-2-phenylacetate; With 1,8-diazabicyclo[5.4.0]undec-7-ene; lithium chloride; In tetrahydrofuran; at 20 ℃; for 0.0833333h; Further stages.;

DOI:10.1016/j.tetasy.2007.09.033

Reference yield: 89.0%

methyl (S)-2-[2-(dimethoxyphosphoryl)acetamido]-2-phenylacetate (1000619-63-5) → (S)-2-(2-dimethoxyphosphoryl)acetamido-2-phenylethanol (1000619-64-6)

Guidance literature:

With sodium tetrahydroborate; In tetrahydrofuran; methanol; for 1.33333h; Heating;

DOI:10.1016/j.tetasy.2007.09.033

upstream raw materials:

methyl (S)-2-(2-bromoacetamido)-2-phenylacetate

phosphorous acid trimethyl ester

Downstream raw materials:

(S)-2-(2-dimethoxyphosphoryl)acetamido-2-phenylethanol