C₁₈H₁₅N₅

Base Information

• Chemical Name: C₁₈H₁₅N₅
• CAS No.: 1377153-80-4
• Molecular Formula: C₁₈H₁₅N₅
• Molecular Weight: 301.351
• Mol file: 1377153-80-4.mol

Synonyms:C₁₈H₁₅N₅

Chemical Property of C₁₈H₁₅N₅

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₁₈H₁₅N₅

There total 5 articles about C₁₈H₁₅N₅ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 32.0%

potassium cyanide + (Z)-4-chloro-4-[4-(diethylamino)phenyl]buta-1,3-diene-1,1,2-tricarbonitrile (1377153-85-9) → C18H15N5 (1377153-80-4)

Guidance literature:

potassium cyanide; (Z)-4-chloro-4-[4-(diethylamino)phenyl]buta-1,3-diene-1,1,2-tricarbonitrile; With tetrakis(triphenylphosphine) palladium⁽⁰⁾; 18-crown-6 ether; In toluene; at 95 ℃; for 1.5h;

With copper(l) cyanide; In N,N-dimethyl-formamide; toluene; at 95 ℃;

DOI:10.1002/ejoc.201200111

Reference yield:

4-ethynyl-N,N-diethylaniline (41876-70-4) → C18H15N5 (1377153-80-4)

Guidance literature:

Multi-step reaction with 2 steps

1.1: acetonitrile / 2 h / 90 °C

2.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; 18-crown-6 ether / toluene / 1.5 h / 95 °C

2.2: 95 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; 18-crown-6 ether; In toluene; acetonitrile;

DOI:10.1002/ejoc.201200111

Reference yield:

p-aminoiodobenzene (540-37-4) → C18H15N5 (1377153-80-4)

Guidance literature:

Multi-step reaction with 5 steps

1.1: sodium carbonate / N,N-dimethyl-formamide / 14 h / 70 °C

2.1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; diisopropylamine / 14 h / 20 °C / Inert atmosphere

3.1: potassium carbonate / methanol / 2 h / 20 °C

4.1: acetonitrile / 2 h / 90 °C

5.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; 18-crown-6 ether / toluene / 1.5 h / 95 °C

5.2: 95 °C

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; 18-crown-6 ether; sodium carbonate; potassium carbonate; diisopropylamine; In methanol; N,N-dimethyl-formamide; toluene; acetonitrile;

DOI:10.1002/ejoc.201200111

upstream raw materials:

(Z)-4-chloro-4-[4-(diethylamino)phenyl]buta-1,3-diene-1,1,2-tricarbonitrile

4-ethynyl-N,N-diethylaniline

N,N-diethyl-4-iodo-aniline

p-aminoiodobenzene