10-chloro-5-{[1-(N,N-dimethylglycyl)-5-(methyloxy)-2,3-dihydro-1H-indol-6-yl]amino}-8-fluoro-3-[(4-methylphenyl)sulfonyl]-3,12-dihydro-7H-6l5-pyrrolo[2',3':4,5]pyrimido[6,1-b]quinazolin-7-one

Base Information

Chemical Name:10-chloro-5-{[1-(N,N-dimethylglycyl)-5-(methyloxy)-2,3-dihydro-1H-indol-6-yl]amino}-8-fluoro-3-[(4-methylphenyl)sulfonyl]-3,12-dihydro-7H-6l5-pyrrolo[2',3':4,5]pyrimido[6,1-b]quinazolin-7-one
CAS No.:1116240-61-9
Molecular Formula:C₃₃H₂₉ClFN₇O₅S
Molecular Weight:690.155
Hs Code.:

10-chloro-5-{[1-(N,N-dimethylglycyl)-5-(methyloxy)-2,3-dihydro-1H-indol-6-yl]amino}-8-fluoro-3-[(4-methylphenyl)sulfonyl]-3,12-dihydro-7H-6l5-pyrrolo[2',3':4,5]pyrimido[6,1-b]quinazolin-7-one

Synonyms:10-chloro-5-{[1-(N,N-dimethylglycyl)-5-(methyloxy)-2,3-dihydro-1H-indol-6-yl]amino}-8-fluoro-3-[(4-methylphenyl)sulfonyl]-3,12-dihydro-7H-6l5-pyrrolo[2',3':4,5]pyrimido[6,1-b]quinazolin-7-one

Suppliers and Price of 10-chloro-5-{[1-(N,N-dimethylglycyl)-5-(methyloxy)-2,3-dihydro-1H-indol-6-yl]amino}-8-fluoro-3-[(4-methylphenyl)sulfonyl]-3,12-dihydro-7H-6l5-pyrrolo[2',3':4,5]pyrimido[6,1-b]quinazolin-7-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 10-chloro-5-{[1-(N,N-dimethylglycyl)-5-(methyloxy)-2,3-dihydro-1H-indol-6-yl]amino}-8-fluoro-3-[(4-methylphenyl)sulfonyl]-3,12-dihydro-7H-6l5-pyrrolo[2',3':4,5]pyrimido[6,1-b]quinazolin-7-one

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 10-chloro-5-{[1-(N,N-dimethylglycyl)-5-(methyloxy)-2,3-dihydro-1H-indol-6-yl]amino}-8-fluoro-3-[(4-methylphenyl)sulfonyl]-3,12-dihydro-7H-6l5-pyrrolo[2',3':4,5]pyrimido[6,1-b]quinazolin-7-one

There total 1 articles about 10-chloro-5-{[1-(N,N-dimethylglycyl)-5-(methyloxy)-2,3-dihydro-1H-indol-6-yl]amino}-8-fluoro-3-[(4-methylphenyl)sulfonyl]-3,12-dihydro-7H-6l5-pyrrolo[2',3':4,5]pyrimido[6,1-b]quinazolin-7-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1116229-84-5
1-[(dimethylamino)acetyl]-5-(methyloxy)-2,3-dihydro-1H-indol-6-amine

: 1116233-54-5
4-chloro-2-({2-chloro-7-[(4-methylphenyl)sulfonyl]-7H-pyrrolo[2,3-d]pyrimidin-4-yl}amino)-6-fluorobenzamide

: 1116240-61-9
10-chloro-5-{[1-(N,N-dimethylglycyl)-5-(methyloxy)-2,3-dihydro-1H-indol-6-yl]amino}-8-fluoro-3-[(4-methylphenyl)sulfonyl]-3,12-dihydro-7H-6l5-pyrrolo[2',3':4,5]pyrimido[6,1-b]quinazolin-7-one

Guidance literature:: 1-[(dimethylamino)acetyl]-5-(methyloxy)-2,3-dihydro-1H-indol-6-amine; 4-chloro-2-({2-chloro-7-[(4-methylphenyl)sulfonyl]-7H-pyrrolo[2,3-d]pyrimidin-4-yl}amino)-6-fluorobenzamide; With hydrogenchloride; potassium iodide; In 1,4-dioxane; 2,2,2-trifluoroethanol; at 80 ℃; for 12h;

With sodium hydrogencarbonate; In 1,4-dioxane; dichloromethane; 2,2,2-trifluoroethanol; water; at 20 ℃;

Reference yield:

: 1116240-61-9
10-chloro-5-{[1-(N,N-dimethylglycyl)-5-(methyloxy)-2,3-dihydro-1H-indol-6-yl]amino}-8-fluoro-3-[(4-methylphenyl)sulfonyl]-3,12-dihydro-7H-6l5-pyrrolo[2',3':4,5]pyrimido[6,1-b]quinazolin-7-one

: 1116236-10-2
4-chloro-2-[(2-{[1-(N,N-dimethylglycyl)-5-(methyloxy)-2,3-dihydro-1H-indol-6-yl]amino}-1H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]-6-fluorobenzamide

Guidance literature:: 10-chloro-5-{[1-(N,N-dimethylglycyl)-5-(methyloxy)-2,3-dihydro-1H-indol-6-yl]amino}-8-fluoro-3-[(4-methylphenyl)sulfonyl]-3,12-dihydro-7H-6l5-pyrrolo[2',3':4,5]pyrimido[6,1-b]quinazolin-7-one; With ammonia; In tetrahydrofuran; water; at 20 ℃; for 24h;

With sodium hydroxide; water; In 1,4-dioxane; at 120 ℃; for 0.133333h; microwave irradiation;

Reference yield:

: 1116240-61-9
10-chloro-5-{[1-(N,N-dimethylglycyl)-5-(methyloxy)-2,3-dihydro-1H-indol-6-yl]amino}-8-fluoro-3-[(4-methylphenyl)sulfonyl]-3,12-dihydro-7H-6l5-pyrrolo[2',3':4,5]pyrimido[6,1-b]quinazolin-7-one

: 74-89-5
methylamine

: 1116236-13-5
4-chloro-2-[(2-{[1-(N,N-dimethylglycyl)-5-(methyloxy)-2,3-dihydro-1H-indol-6-yl]amino}-1H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]-6-fluoro-N-methylbenzamide

Guidance literature:: 10-chloro-5-{[1-(N,N-dimethylglycyl)-5-(methyloxy)-2,3-dihydro-1H-indol-6-yl]amino}-8-fluoro-3-[(4-methylphenyl)sulfonyl]-3,12-dihydro-7H-6l5-pyrrolo[2',3':4,5]pyrimido[6,1-b]quinazolin-7-one; methylamine; In tetrahydrofuran; at 20 ℃; for 12h;

With sodium hydroxide; water; In 1,4-dioxane; at 120 ℃; for 0.133333h; microwave irradiation;