(R)-[3-oxo-1-(2,4,5-trifluorobenzyl)-3-(1-bromo-3-trifluoromethyl-5,6-dihydro-8H-imidazo[1,5-a]pyrazin-7-yl)-propyl]-carbamic acid t-butyl ester

Base Information Edit

Chemical Name:(R)-[3-oxo-1-(2,4,5-trifluorobenzyl)-3-(1-bromo-3-trifluoromethyl-5,6-dihydro-8H-imidazo[1,5-a]pyrazin-7-yl)-propyl]-carbamic acid t-butyl ester
CAS No.:1152440-32-8
Molecular Formula:C₂₂H₂₃BrF₆N₄O₃
Molecular Weight:585.344
Hs Code.:
Mol file:1152440-32-8.mol

Synonyms:(R)-[3-oxo-1-(2,4,5-trifluorobenzyl)-3-(1-bromo-3-trifluoromethyl-5,6-dihydro-8H-imidazo[1,5-a]pyrazin-7-yl)-propyl]-carbamic acid t-butyl ester

Suppliers and Price of (R)-[3-oxo-1-(2,4,5-trifluorobenzyl)-3-(1-bromo-3-trifluoromethyl-5,6-dihydro-8H-imidazo[1,5-a]pyrazin-7-yl)-propyl]-carbamic acid t-butyl ester

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (R)-[3-oxo-1-(2,4,5-trifluorobenzyl)-3-(1-bromo-3-trifluoromethyl-5,6-dihydro-8H-imidazo[1,5-a]pyrazin-7-yl)-propyl]-carbamic acid t-butyl ester Edit

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (R)-[3-oxo-1-(2,4,5-trifluorobenzyl)-3-(1-bromo-3-trifluoromethyl-5,6-dihydro-8H-imidazo[1,5-a]pyrazin-7-yl)-propyl]-carbamic acid t-butyl ester

There total 15 articles about (R)-[3-oxo-1-(2,4,5-trifluorobenzyl)-3-(1-bromo-3-trifluoromethyl-5,6-dihydro-8H-imidazo[1,5-a]pyrazin-7-yl)-propyl]-carbamic acid t-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 24424-99-5
di-tert-butyl dicarbonate

: 1152439-77-4
(R)-[3-oxo-1-(2,4,5-trifluorobenzyl)-3-(3-trifluoromethyl-5,6-dihydro-8H-imidazo[1,5-a]pyrazin-7-yl)-propyl]-carbamic acid t-butyl ester

: 1152440-32-8
(R)-[3-oxo-1-(2,4,5-trifluorobenzyl)-3-(1-bromo-3-trifluoromethyl-5,6-dihydro-8H-imidazo[1,5-a]pyrazin-7-yl)-propyl]-carbamic acid t-butyl ester

Guidance literature:: (R)-[3-oxo-1-(2,4,5-trifluorobenzyl)-3-(3-trifluoromethyl-5,6-dihydro-8H-imidazo[1,5-a]pyrazin-7-yl)-propyl]-carbamic acid t-butyl ester; With N-Bromosuccinimide; In ethanol; at 20 ℃; for 1h;

di-tert-butyl dicarbonate; With potassium carbonate; In ethanol; for 1h;

Reference yield: 86.0%

: 1152439-77-4
(R)-[3-oxo-1-(2,4,5-trifluorobenzyl)-3-(3-trifluoromethyl-5,6-dihydro-8H-imidazo[1,5-a]pyrazin-7-yl)-propyl]-carbamic acid t-butyl ester

: 1152440-32-8
(R)-[3-oxo-1-(2,4,5-trifluorobenzyl)-3-(1-bromo-3-trifluoromethyl-5,6-dihydro-8H-imidazo[1,5-a]pyrazin-7-yl)-propyl]-carbamic acid t-butyl ester

Guidance literature:: (R)-[3-oxo-1-(2,4,5-trifluorobenzyl)-3-(3-trifluoromethyl-5,6-dihydro-8H-imidazo[1,5-a]pyrazin-7-yl)-propyl]-carbamic acid t-butyl ester; With N-Bromosuccinimide; In ethanol; for 1h;

With di-tert-butyl dicarbonate; potassium carbonate; In ethanol; for 1h;

Reference yield:

: 209995-38-0
(2,4,5-trifluorophenyl)acetic acid

: 1152440-32-8
(R)-[3-oxo-1-(2,4,5-trifluorobenzyl)-3-(1-bromo-3-trifluoromethyl-5,6-dihydro-8H-imidazo[1,5-a]pyrazin-7-yl)-propyl]-carbamic acid t-butyl ester

Guidance literature:: Multi-step reaction with 7 steps

1.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dmap / dichloromethane / 36 h / 20 °C / Cooling with ice

2.1: ethanol / ethanol / 12 h / 70 °C

3.1: ammonium acetate / methanol / 3 h / Reflux

4.1: hydrogen / chloro(1,5-cyclooctadiene)rhodium(I) dimer; (R)-1-[(S)-2-(diphenyl phosphino)ferrocenyl]-ethyl-tert-butylphosphine / water; methanol / 24 h / 30 °C / 5069.54 Torr

5.1: sodium hydroxide; water / methanol / 1.5 h / 40 - 45 °C

5.2: pH 2 - 3

6.1: triethylamine / dichloromethane / 0.08 h

6.2: 2 h

7.1: N-Bromosuccinimide / ethanol / 1 h

7.2: 1 h

With N-Bromosuccinimide; ethanol; ammonium acetate; water; hydrogen; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; sodium hydroxide; dmap; chloro(1,5-cyclooctadiene)rhodium(I) dimer; (R)-1-[(S)-2-(diphenyl phosphino)ferrocenyl]-ethyl-tert-butylphosphine; In methanol; ethanol; dichloromethane; water;