(R)-[3-oxo-1-(2,4,5-trifluorobenzyl)-3-(3-trifluoromethyl-5,6-dihydro-8H-imidazo[1,5-a]pyrazin-7-yl)-propyl]-carbamic acid t-butyl ester

Base Information

Chemical Name:(R)-[3-oxo-1-(2,4,5-trifluorobenzyl)-3-(3-trifluoromethyl-5,6-dihydro-8H-imidazo[1,5-a]pyrazin-7-yl)-propyl]-carbamic acid t-butyl ester
CAS No.:1152439-77-4
Molecular Formula:C₂₂H₂₄F₆N₄O₃
Molecular Weight:506.448
Hs Code.:

Synonyms:(R)-[3-oxo-1-(2,4,5-trifluorobenzyl)-3-(3-trifluoromethyl-5,6-dihydro-8H-imidazo[1,5-a]pyrazin-7-yl)-propyl]-carbamic acid t-butyl ester

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Chemical Property of (R)-[3-oxo-1-(2,4,5-trifluorobenzyl)-3-(3-trifluoromethyl-5,6-dihydro-8H-imidazo[1,5-a]pyrazin-7-yl)-propyl]-carbamic acid t-butyl ester

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Technology Process of (R)-[3-oxo-1-(2,4,5-trifluorobenzyl)-3-(3-trifluoromethyl-5,6-dihydro-8H-imidazo[1,5-a]pyrazin-7-yl)-propyl]-carbamic acid t-butyl ester

There total 12 articles about (R)-[3-oxo-1-(2,4,5-trifluorobenzyl)-3-(3-trifluoromethyl-5,6-dihydro-8H-imidazo[1,5-a]pyrazin-7-yl)-propyl]-carbamic acid t-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 959238-29-0
3-trifluoromethyl-5,6,7,8-tetrahydro-imidazo [1,5-a] pyrazine

: 486460-00-8,922178-94-7
(3R)-3-[(1,1-dimethylethoxycarbonyl)amino]-4-(2,4,5-trifluorophenyl)butanoic acid

: 1152439-77-4
(R)-[3-oxo-1-(2,4,5-trifluorobenzyl)-3-(3-trifluoromethyl-5,6-dihydro-8H-imidazo[1,5-a]pyrazin-7-yl)-propyl]-carbamic acid t-butyl ester

Guidance literature:: 3-trifluoromethyl-5,6,7,8-tetrahydro-imidazo [1,5-a] pyrazine; With triethylamine; In dichloromethane; at 20 ℃; for 0.0833333h; Inert atmosphere;

(3R)-3-[(1,1-dimethylethoxycarbonyl)amino]-4-(2,4,5-trifluorophenyl)butanoic acid; With bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; In dichloromethane; at 20 ℃; for 2h;

Reference yield: 88.0%

: 1368173-92-5
1-(trifluoromethyl)-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine

: 486460-00-8,922178-94-7
(3R)-3-[(1,1-dimethylethoxycarbonyl)amino]-4-(2,4,5-trifluorophenyl)butanoic acid

: 1152439-77-4
(R)-[3-oxo-1-(2,4,5-trifluorobenzyl)-3-(3-trifluoromethyl-5,6-dihydro-8H-imidazo[1,5-a]pyrazin-7-yl)-propyl]-carbamic acid t-butyl ester

Guidance literature:: (3R)-3-[(1,1-dimethylethoxycarbonyl)amino]-4-(2,4,5-trifluorophenyl)butanoic acid; With triethylamine; In dichloromethane; for 0.0833333h;

1-(trifluoromethyl)-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine; With bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; In dichloromethane; for 2h;

Reference yield:

: 209995-38-0
(2,4,5-trifluorophenyl)acetic acid

: 1152439-77-4
(R)-[3-oxo-1-(2,4,5-trifluorobenzyl)-3-(3-trifluoromethyl-5,6-dihydro-8H-imidazo[1,5-a]pyrazin-7-yl)-propyl]-carbamic acid t-butyl ester

Guidance literature:: Multi-step reaction with 6 steps

1.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dmap / dichloromethane / 36 h / 20 °C / Cooling with ice

2.1: ethanol / ethanol / 12 h / 70 °C

3.1: ammonium acetate / methanol / 3 h / Reflux

4.1: hydrogen / chloro(1,5-cyclooctadiene)rhodium(I) dimer; (R)-1-[(S)-2-(diphenyl phosphino)ferrocenyl]-ethyl-tert-butylphosphine / water; methanol / 24 h / 30 °C / 5069.54 Torr

5.1: sodium hydroxide; water / methanol / 1.5 h / 40 - 45 °C

5.2: pH 2 - 3

6.1: triethylamine / dichloromethane / 0.08 h

6.2: 2 h

With ethanol; ammonium acetate; water; hydrogen; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; sodium hydroxide; dmap; chloro(1,5-cyclooctadiene)rhodium(I) dimer; (R)-1-[(S)-2-(diphenyl phosphino)ferrocenyl]-ethyl-tert-butylphosphine; In methanol; ethanol; dichloromethane; water;