α-(5-aminopentyl)-3,4-dimethoxy-α-<(4-methylphenyl)thio>benzeneacetonitrile

Base Information

Chemical Name:α-(5-aminopentyl)-3,4-dimethoxy-α-<(4-methylphenyl)thio>benzeneacetonitrile
CAS No.:167159-52-6
Molecular Formula:C₂₂H₂₈N₂O₂S
Molecular Weight:384.543
Hs Code.:

Synonyms:α-(5-aminopentyl)-3,4-dimethoxy-α-<(4-methylphenyl)thio>benzeneacetonitrile

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of α-(5-aminopentyl)-3,4-dimethoxy-α-<(4-methylphenyl)thio>benzeneacetonitrile

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Technology Process of α-(5-aminopentyl)-3,4-dimethoxy-α-<(4-methylphenyl)thio>benzeneacetonitrile

There total 8 articles about α-(5-aminopentyl)-3,4-dimethoxy-α-<(4-methylphenyl)thio>benzeneacetonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.8%

: 167158-91-0
α-(3,4-dimethoxyphenyl)-1,3-dihydro-α-<(4-methylphenyl)thio>-1,3-dioxo-2H-isoindole-2-heptanenitrile

: 167159-52-6
α-(5-aminopentyl)-3,4-dimethoxy-α-<(4-methylphenyl)thio>benzeneacetonitrile

Guidance literature:: With hydrazine hydrate; In ethanol; for 1.5h; Heating;
DOI:10.1021/jm9804477

Reference yield:

: 64-17-5
ethanol

: 167158-91-0
α-(3,4-dimethoxyphenyl)-1,3-dihydro-α-<(4-methylphenyl)thio>-1,3-dioxo-2H-isoindole-2-heptanenitrile

: 167159-52-6
α-(5-aminopentyl)-3,4-dimethoxy-α-<(4-methylphenyl)thio>benzeneacetonitrile

Guidance literature:: With hydrogenchloride; hydrazine hydrate; In chloroform;

Reference yield:

: 28750-77-8
α-chloro-3,4-dimetoxybenzeneacetonitrile

: 167159-52-6
α-(5-aminopentyl)-3,4-dimethoxy-α-<(4-methylphenyl)thio>benzeneacetonitrile

Guidance literature:: Multi-step reaction with 5 steps

1: 65 percent / K₂CO₃ / acetonitrile / 12 h / 65 °C

2: 1.) NaH / 1.) DMSO, 25 deg C, 1.5 h, 2.) DMSO, 25 deg C, 3 h

3: 6.24 g / NaI / acetone / 12 h / Heating

4: 83 percent / dimethylformamide / 2 h / 100 °C

5: 99.8 percent / NH₂NH₂*H₂O / ethanol / 1.5 h / Heating

With sodium hydride; potassium carbonate; hydrazine hydrate; sodium iodide; In ethanol; N,N-dimethyl-formamide; acetone; acetonitrile;
DOI:10.1021/jm9804477