Technology Process of 4-(bromomethyl)-3-phenylfuran-2(5H)-one
There total 7 articles about 4-(bromomethyl)-3-phenylfuran-2(5H)-one which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 4 h / 160 °C
2: potassium hydroxide / ethanol; water / 5 h / 23 °C
3: triethylamine; tetra-(n-butyl)ammonium iodide / N,N-dimethyl-formamide / 3 h / 0 - 23 °C
4: lithium hexamethyldisilazane / tetrahydrofuran / 14 h / -78 - 23 °C / Inert atmosphere
5: acetyl chloride; methanol / 23 - 50 °C / Inert atmosphere
6: phosphorus tribromide / Inert atmosphere
With
methanol; phosphorus tribromide; tetra-(n-butyl)ammonium iodide; triethylamine; acetyl chloride; potassium hydroxide; lithium hexamethyldisilazane;
In
tetrahydrofuran; ethanol; water; N,N-dimethyl-formamide;
1: |Arbuzov Reaction / 4: |Horner-Wadsworth-Emmons Olefination;
DOI:10.1021/jo501302f
- Guidance literature:
-
Multi-step reaction with 5 steps
1: potassium hydroxide / ethanol; water / 5 h / 23 °C
2: triethylamine; tetra-(n-butyl)ammonium iodide / N,N-dimethyl-formamide / 3 h / 0 - 23 °C
3: lithium hexamethyldisilazane / tetrahydrofuran / 14 h / -78 - 23 °C / Inert atmosphere
4: acetyl chloride; methanol / 23 - 50 °C / Inert atmosphere
5: phosphorus tribromide / Inert atmosphere
With
methanol; phosphorus tribromide; tetra-(n-butyl)ammonium iodide; triethylamine; acetyl chloride; potassium hydroxide; lithium hexamethyldisilazane;
In
tetrahydrofuran; ethanol; water; N,N-dimethyl-formamide;
3: |Horner-Wadsworth-Emmons Olefination;
DOI:10.1021/jo501302f
- Guidance literature:
-
Multi-step reaction with 4 steps
1: triethylamine; tetra-(n-butyl)ammonium iodide / N,N-dimethyl-formamide / 3 h / 0 - 23 °C
2: lithium hexamethyldisilazane / tetrahydrofuran / 14 h / -78 - 23 °C / Inert atmosphere
3: acetyl chloride; methanol / 23 - 50 °C / Inert atmosphere
4: phosphorus tribromide / Inert atmosphere
With
methanol; phosphorus tribromide; tetra-(n-butyl)ammonium iodide; triethylamine; acetyl chloride; lithium hexamethyldisilazane;
In
tetrahydrofuran; N,N-dimethyl-formamide;
2: |Horner-Wadsworth-Emmons Olefination;
DOI:10.1021/jo501302f
