38654-91-0

Upstream product

• 67683-19-6 (diethoxyphosphinyl)phenylketene 
• 124-38-9 carbon dioxide 
• 1080-32-6 O,O-diethyl benzylphosphonate 
• 31641-78-8 ethyl 2-diethoxyphosphoryl-2-phenylacetate 
• 2882-19-1 ethyl 2-phenyl-2-bromoacetate 
• 101-97-3 Ethyl 2-phenylethanoate 
• 59356-28-4 C₁₄H₂₁O₄P 
• 37167-62-7 bromo-phenyl-acetic acid methyl ester 
• 51863-47-9 (diethoxyphosphoryl)-phenyl-acetic acid methyl ester 

Downstream Products

• 91-48-5 (E)-2,3-diphenylpropenoic acid 
• 78427-50-6 (E)-2-Phenyl-hex-2-enoic acid 
• 78427-51-7 (E)-4-Methyl-2-phenyl-pent-2-enoic acid 
• 53615-31-9 (Chlorocarbonyl-phenyl-methyl)-phosphonic acid diethyl ester 
• 38428-05-6 diethyl ether of α-(N-benzyloxycarbonyl)aminobenzylphosphonic acid 
• 25944-64-3 diethyl (1-phenylethenyl)phosphonate 
• 22894-35-5 2-oxo-1-phenylpropylphosphonate de diethyle 
• 109632-31-7 2-oxo-1-phenylbutylphosphonate de diethyle 
• 955-10-2 3-phenylcumarin 
• 23028-23-1 4-methyl-3-phenyl-2H-1-benzopyran-2-one 
• 2859-29-2 1-methyl-3-phenylquinolin-2(1H)-one 
• 2555-22-8 3-phenyl-7-methoxycoumarin 
• 67683-19-6 (diethoxyphosphinyl)phenylketene 
• 73220-25-4 3-phenyl-2H-benzo[g]chromen-2-one 

Relevant academic research and scientific papers

An intramolecular [2 + 2] photocycloaddition approach to conformationally restricted bis-pyrrolidines

With N-Boc-protected 4-(allylaminomethyl)-2(5H)furanones as starting materials, a photochemical approach is presented to give 3,9-diazatricyclo[5.3. 0.01,5]decanes as conformationally restricted bis-pyrrolidines. The products are orthogonally protected at the two nitrogen atoms and exhibit, depending on the substitution pattern at positions C5, C6, and C7, latent C 2 symmetry. When the furanones had a phenyl group at the 3-position (X3), alternative photochemical pathways were observed.

A novel three-component butenolide synthesis.

[reaction: see text]. 5-Acylamino butenolides can be assembled by a multicomponent reaction (MCR) of isocyanides, glyoxals, and acetophosphonic acid diethylesters, followed by a intramolecular Wittig-type reaction. The reaction can be performed either in one pot or with the isolation of the intermediate Passerini product. This versatile reaction offers three independent inputs displayed in the final product. Applications in combinatorial chemistry and natural product synthesis can be envisioned.

A useful synthesis of diethyl 1-substituted vinylphosphonates

A variety of diethyl 1-substituted vinylphosphonates 8 has been conveniently synthesized by piperidine catalyzed decarboxylative condensation of 2-diethoxyphosphorylalkanoic acids and 2-diethoxyphosphorylalkenoic acids 7 with formaldehyde.

Potential GABAB Receptor Antagonists. X* the Synthesis of Further Analogues of Baclofen, Phaclbfen and Saclofen

In an attempt to obtain new compounds with binding activity at the GABAB receptor site, we report the synthesis of 3-amino-2-arylpropanoic acids, and the sulfonic, phosphonic and hydroxamic acid analogues. In addition, we report the synthesis of the isomer of phaclofen, 3-amino-1-(4-chlorophenyl)-propylphosphonic acid, and the higher homologue of baclofen, 5-amino-2-(4-chlorophenyl)pentanoic acid.

A Facile and General, One-pot Synthesis of 2-Oxoalkane Phosphonates from Diethylphosphonocarboxylic Acid Chlorides and Organometallic Reagents

An efficient and general method for the preparation of 2-oxoalkane phosphonates 2 is described.Diethylphosphono-2-alkanoyl chlorides are used to introduce directly the 2-oxophosphonate 1-substituted synthons on Grignard or cuprate reagents.