phenyl-{1-[3-(3-trifluoromethyl-phenyl)-prop-2-ynyl]-1H-indol-2-yl}-methanone

Base Information

Chemical Name:phenyl-{1-[3-(3-trifluoromethyl-phenyl)-prop-2-ynyl]-1H-indol-2-yl}-methanone
CAS No.:853052-28-5
Molecular Formula:C₂₅H₁₆F₃NO
Molecular Weight:403.403
Hs Code.:

Synonyms:phenyl-{1-[3-(3-trifluoromethyl-phenyl)-prop-2-ynyl]-1H-indol-2-yl}-methanone

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of phenyl-{1-[3-(3-trifluoromethyl-phenyl)-prop-2-ynyl]-1H-indol-2-yl}-methanone

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Technology Process of phenyl-{1-[3-(3-trifluoromethyl-phenyl)-prop-2-ynyl]-1H-indol-2-yl}-methanone

There total 2 articles about phenyl-{1-[3-(3-trifluoromethyl-phenyl)-prop-2-ynyl]-1H-indol-2-yl}-methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 853052-23-0
phenyl(1-prop-2-ynyl-1H-indol-2-yl)methanone

: 401-81-0
m-trifluoromethylphenyl iodide

: 853052-28-5
phenyl-{1-[3-(3-trifluoromethyl-phenyl)-prop-2-ynyl]-1H-indol-2-yl}-methanone

Guidance literature:: With copper(l) iodide; potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In N,N-dimethyl-formamide; at 60 ℃; for 2h;
DOI:10.1021/jo0502246

Reference yield:

: 1022-86-2
2-benzoylindole

: 853052-28-5
phenyl-{1-[3-(3-trifluoromethyl-phenyl)-prop-2-ynyl]-1H-indol-2-yl}-methanone

Guidance literature:: Multi-step reaction with 2 steps

1: 98 percent / tetrabutylammonium bromide; sodium hydroxyde / toluene; H₂O / 5 h / 20 °C

2: 81 percent / potassium carbonate; CuI / tetrakis(triphenylphosphine)palladium⁽⁰⁾ / dimethylformamide / 2 h / 60 °C

With sodium hydroxide; copper(l) iodide; tetrabutylammomium bromide; potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In water; N,N-dimethyl-formamide; toluene; 2: Sonogashira coupling;
DOI:10.1021/jo0502246