2-(4-(4-(5-(2-phenyl-5-(trifluoromethyl)oxazole-4-carboxamido)-1H-benzo[d]imidazol-2-yl)phenyl)cyclohexyl)acetic acid

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Chemical Name:2-(4-(4-(5-(2-phenyl-5-(trifluoromethyl)oxazole-4-carboxamido)-1H-benzo[d]imidazol-2-yl)phenyl)cyclohexyl)acetic acid
CAS No.:1448669-92-8
Molecular Formula:C₃₂H₂₇F₃N₄O₄
Molecular Weight:588.586
Hs Code.:

Synonyms:2-(4-(4-(5-(2-phenyl-5-(trifluoromethyl)oxazole-4-carboxamido)-1H-benzo[d]imidazol-2-yl)phenyl)cyclohexyl)acetic acid

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Chemical Property of 2-(4-(4-(5-(2-phenyl-5-(trifluoromethyl)oxazole-4-carboxamido)-1H-benzo[d]imidazol-2-yl)phenyl)cyclohexyl)acetic acid

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Technology Process of 2-(4-(4-(5-(2-phenyl-5-(trifluoromethyl)oxazole-4-carboxamido)-1H-benzo[d]imidazol-2-yl)phenyl)cyclohexyl)acetic acid

There total 6 articles about 2-(4-(4-(5-(2-phenyl-5-(trifluoromethyl)oxazole-4-carboxamido)-1H-benzo[d]imidazol-2-yl)phenyl)cyclohexyl)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 1448670-02-7
ethyl 2-(4-(4-(5-(2-phenyl-5-(trifluoromethyl)oxazole-4-carboxamido)-1H-benzo[d]imidazol-2-yl)phenyl)cyclohexyl)acetate

: 1448669-92-8
2-(4-(4-(5-(2-phenyl-5-(trifluoromethyl)oxazole-4-carboxamido)-1H-benzo[d]imidazol-2-yl)phenyl)cyclohexyl)acetic acid

Guidance literature:: With lithium hydroxide monohydrate; In tetrahydrofuran; ethanol; water; at 25 ℃; for 18h;
DOI:10.1016/j.bmcl.2013.05.081

Reference yield:

: 4894-75-1
1-phenyl-4-cyclohexanone

: 1448669-92-8
2-(4-(4-(5-(2-phenyl-5-(trifluoromethyl)oxazole-4-carboxamido)-1H-benzo[d]imidazol-2-yl)phenyl)cyclohexyl)acetic acid

Guidance literature:: Multi-step reaction with 7 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 0 - 20 °C

1.2: 4 h / 0 °C

2.1: palladium 10% on activated carbon; hydrogen / ethanol / 18 h / 20 °C

3.1: titanium tetrachloride / dichloromethane / 4 h / 0 - 20 °C / Inert atmosphere

4.1: Oxone / N,N-dimethyl-formamide; water / 24 h / 25 °C

5.1: palladium 10% on activated carbon; hydrogen / ethanol / 18 h / 20 °C

6.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / dichloromethane / 18 h / 20 °C

7.1: lithium hydroxide monohydrate / tetrahydrofuran; ethanol; water / 18 h / 25 °C

With lithium hydroxide monohydrate; palladium 10% on activated carbon; Oxone; hydrogen; titanium tetrachloride; sodium hydride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In tetrahydrofuran; ethanol; dichloromethane; water; N,N-dimethyl-formamide; mineral oil; 1.1: |Horner-Wadsworth-Emmons Olefination - Still-Gennari Modification / 1.2: |Horner-Wadsworth-Emmons Olefination;
DOI:10.1016/j.bmcl.2013.05.081

Reference yield:

: 115880-04-1
ethyl 2-(4-phenylcyclohexylidene)acetate

: 1448669-92-8
2-(4-(4-(5-(2-phenyl-5-(trifluoromethyl)oxazole-4-carboxamido)-1H-benzo[d]imidazol-2-yl)phenyl)cyclohexyl)acetic acid

Guidance literature:: Multi-step reaction with 6 steps

1: palladium 10% on activated carbon; hydrogen / ethanol / 18 h / 20 °C

2: titanium tetrachloride / dichloromethane / 4 h / 0 - 20 °C / Inert atmosphere

3: Oxone / N,N-dimethyl-formamide; water / 24 h / 25 °C

4: palladium 10% on activated carbon; hydrogen / ethanol / 18 h / 20 °C

5: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / dichloromethane / 18 h / 20 °C

6: lithium hydroxide monohydrate / tetrahydrofuran; ethanol; water / 18 h / 25 °C

With lithium hydroxide monohydrate; palladium 10% on activated carbon; Oxone; hydrogen; titanium tetrachloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In tetrahydrofuran; ethanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2013.05.081