D-Glucitol, 2-deoxy-2-(1,1-dimethylethoxy)carbonylamino-5,6-O-(1-methylethylidene)-3-O-(phenylmethyl)-1-O-(triphenylmethyl)-, 4-methanesulfonate

Base Information

Chemical Name:D-Glucitol, 2-deoxy-2-(1,1-dimethylethoxy)carbonylamino-5,6-O-(1-methylethylidene)-3-O-(phenylmethyl)-1-O-(triphenylmethyl)-, 4-methanesulfonate
CAS No.:163707-57-1
Molecular Formula:C41H49 N O9 S
Molecular Weight:731.89
Hs Code.:
Mol file:163707-57-1.mol

D-Glucitol, 2-deoxy-2-(1,1-dimethylethoxy)carbonylamino-5,6-O-(1-methylethylidene)-3-O-(phenylmethyl)-1-O-(triphenylmethyl)-, 4-methanesulfonate

Synonyms:D-Glucitol, 2-deoxy-2-(1,1-dimethylethoxy)carbonylamino-5,6-O-(1-methylethylidene)-3-O-(phenylmethyl)-1-O-(triphenylmethyl)-, 4-methanesulfonate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of D-Glucitol, 2-deoxy-2-(1,1-dimethylethoxy)carbonylamino-5,6-O-(1-methylethylidene)-3-O-(phenylmethyl)-1-O-(triphenylmethyl)-, 4-methanesulfonate

Chemical Property:

Boiling Point:828.1±65.0 °C(Predicted)
PKA:11.21±0.46(Predicted)
PSA：127.00000
Density:1.196±0.06 g/cm3(Predicted)
LogP:8.44180

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of D-Glucitol, 2-deoxy-2-(1,1-dimethylethoxy)carbonylamino-5,6-O-(1-methylethylidene)-3-O-(phenylmethyl)-1-O-(triphenylmethyl)-, 4-methanesulfonate

There total 10 articles about D-Glucitol, 2-deoxy-2-(1,1-dimethylethoxy)carbonylamino-5,6-O-(1-methylethylidene)-3-O-(phenylmethyl)-1-O-(triphenylmethyl)-, 4-methanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 124-63-0
methanesulfonyl chloride

: 163707-56-0
3-O-benzyl-2-t-butyloxycarbonylamino-2-deoxy-5,6-O-isopropylidene-1-O-triphenylmethyl-D-glucitol

: 163707-57-1
3-O-benzyl-2-t-butyloxycarbonylamino-2-deoxy-5,6-O-isopropylidene-4-O-methanesulfonyl-1-O-triphenylmethyl-D-glucitol

Guidance literature:: With dmap; In pyridine; Ambient temperature;
DOI:10.1016/S0040-4020(01)89338-8

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 163707-57-1
3-O-benzyl-2-t-butyloxycarbonylamino-2-deoxy-5,6-O-isopropylidene-4-O-methanesulfonyl-1-O-triphenylmethyl-D-glucitol

Guidance literature:: Multi-step reaction with 3 steps

1: KHCO₃ / dioxane; H₂O / Ambient temperature

2: 85 percent / 4-dimethylaminopyridine / pyridine / Ambient temperature

3: 97 percent / 4-dimethylaminopyridine / pyridine / Ambient temperature

With dmap; potassium hydrogencarbonate; In 1,4-dioxane; pyridine; water;
DOI:10.1016/S0040-4020(01)89338-8

Reference yield:

: 100-39-0
benzyl bromide

: 163707-57-1
3-O-benzyl-2-t-butyloxycarbonylamino-2-deoxy-5,6-O-isopropylidene-4-O-methanesulfonyl-1-O-triphenylmethyl-D-glucitol

Guidance literature:: Multi-step reaction with 8 steps

1: 80percent oily NaH / dimethylformamide / Ambient temperature

2: 10percent aq. HOAc / methanol / 7 h / Ambient temperature

3: NaBH₄ / methanol / 1 h / Ambient temperature

4: pyridine / Ambient temperature

5: 1M aq. NaOH / methanol / 7 h / Heating

6: KHCO₃ / dioxane; H₂O / Ambient temperature

7: 85 percent / 4-dimethylaminopyridine / pyridine / Ambient temperature

8: 97 percent / 4-dimethylaminopyridine / pyridine / Ambient temperature

With dmap; sodium hydroxide; sodium tetrahydroborate; sodium hydride; potassium hydrogencarbonate; acetic acid; In 1,4-dioxane; pyridine; methanol; water; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4020(01)89338-8