Technology Process of 2-cyclopropyl-N-(3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl)-4-methyl-2,3,4,5-tetrahydropyrido[3,2-f][1,4]oxazepin-8-amine
There total 5 articles about 2-cyclopropyl-N-(3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl)-4-methyl-2,3,4,5-tetrahydropyrido[3,2-f][1,4]oxazepin-8-amine which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
3-methoxy-4-(4-methyl-1H-imidazol-1-yl)aniline; 8-chloro-2-cyclopropyl-4-methyl-2,3,4,5-tetrahydropyrido[3,2-f][1,4]oxazepine;
With
caesium carbonate;
palladium diacetate; CyJohnPhos;
In
1,2-dimethoxyethane;
at 100 ℃;
for 2h;
Inert atmosphere;
Sealed microwave vial;
With
ethanol;
acetato(2'-di-tert-butylphosphino-1,1'-biphenyl-2-yl)-palladium;
In
1,2-dimethoxyethane;
at 100 ℃;
for 0.5h;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: sodium hydride / tetrahydrofuran; mineral oil / 0 °C
2.1: acetic acid / methanol / 20 °C
3.1: caesium carbonate / palladium diacetate; CyJohnPhos / 1,2-dimethoxyethane / 2 h / 100 °C / Inert atmosphere; Sealed microwave vial
3.2: 0.5 h / 100 °C
With
sodium hydride; caesium carbonate; acetic acid;
palladium diacetate; CyJohnPhos;
In
tetrahydrofuran; methanol; 1,2-dimethoxyethane; mineral oil;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: hydrogen / palladium 10% on activated carbon / methanol / 24 h / 1654.92 Torr
2.1: sodium tris(acetoxy)borohydride; acetic acid / 1,2-dichloro-ethane / 20 °C
3.1: sodium hydride / tetrahydrofuran; mineral oil / 0 °C
4.1: acetic acid / methanol / 20 °C
5.1: caesium carbonate / palladium diacetate; CyJohnPhos / 1,2-dimethoxyethane / 2 h / 100 °C / Inert atmosphere; Sealed microwave vial
5.2: 0.5 h / 100 °C
With
hydrogen; sodium tris(acetoxy)borohydride; sodium hydride; caesium carbonate; acetic acid;
palladium 10% on activated carbon; palladium diacetate; CyJohnPhos;
In
tetrahydrofuran; methanol; 1,2-dimethoxyethane; 1,2-dichloro-ethane; mineral oil;