(2S,3S)-3-[(tert-butoxylcarbonyl)amino]-4-((3S)-3-fluoropyrrolidin-1-yl)-2-[4-(N-butoxycarboxylcyclohexyl)]-N,N-dimethyl-4-oxobutanamide

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Chemical Name:(2S,3S)-3-[(tert-butoxylcarbonyl)amino]-4-((3S)-3-fluoropyrrolidin-1-yl)-2-[4-(N-butoxycarboxylcyclohexyl)]-N,N-dimethyl-4-oxobutanamide
CAS No.:870784-23-9
Molecular Formula:C₂₆H₄₄FN₃O₆
Molecular Weight:513.65
Hs Code.:

Synonyms:(2S,3S)-3-[(tert-butoxylcarbonyl)amino]-4-((3S)-3-fluoropyrrolidin-1-yl)-2-[4-(N-butoxycarboxylcyclohexyl)]-N,N-dimethyl-4-oxobutanamide

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Chemical Property of (2S,3S)-3-[(tert-butoxylcarbonyl)amino]-4-((3S)-3-fluoropyrrolidin-1-yl)-2-[4-(N-butoxycarboxylcyclohexyl)]-N,N-dimethyl-4-oxobutanamide

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Technology Process of (2S,3S)-3-[(tert-butoxylcarbonyl)amino]-4-((3S)-3-fluoropyrrolidin-1-yl)-2-[4-(N-butoxycarboxylcyclohexyl)]-N,N-dimethyl-4-oxobutanamide

There total 11 articles about (2S,3S)-3-[(tert-butoxylcarbonyl)amino]-4-((3S)-3-fluoropyrrolidin-1-yl)-2-[4-(N-butoxycarboxylcyclohexyl)]-N,N-dimethyl-4-oxobutanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 870773-56-1
(3S)-1-[(2S,3S)-3-(4-(N-butoxycarbonyl)phenyl)-2-(tert-butoxycarbonylamino)-3-(dimethylaminocarbonyl)-1-oxopropanyl]-3-difluoropyrrolidine

: 870784-23-9
(2S,3S)-3-[(tert-butoxylcarbonyl)amino]-4-((3S)-3-fluoropyrrolidin-1-yl)-2-[4-(N-butoxycarboxylcyclohexyl)]-N,N-dimethyl-4-oxobutanamide

Guidance literature:: With hydrogen; acetic acid; platinum(IV) oxide; for 48h; under 2888.19 Torr;
DOI:10.1016/j.bmcl.2007.02.066

Reference yield:

: 690258-03-8
(βS)-4-bromo-N-(tert-butoxycarbonyl)-β-[(1E)-prop-1-en-1-yl]-L-phenylalanine

: 870784-23-9
(2S,3S)-3-[(tert-butoxylcarbonyl)amino]-4-((3S)-3-fluoropyrrolidin-1-yl)-2-[4-(N-butoxycarboxylcyclohexyl)]-N,N-dimethyl-4-oxobutanamide

Guidance literature:: Multi-step reaction with 5 steps

1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / DMF (N,N-dimethyl-formamide) / 16 h / 20 °C

2: potassium permanganate; sodium periodate; potassium carbonate / water; tert-butyl alcohol

3: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 16 h / 20 °C

4: triethylamine / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 24 h / 90 °C / 760.05 Torr

5: hydrogen; acetic acid / platinum(IV) oxide / 36 h / 20 °C / 2280.15 Torr

With potassium permanganate; sodium periodate; hydrogen; potassium carbonate; benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; platinum(IV) oxide; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; DMF (N,N-dimethyl-formamide); water; tert-butyl alcohol;

Reference yield:

: 690257-97-7
(1S,2E)-3-(4-bromophenyl)-1-methylprop-2-en-1-yl N-(tert-butoxycarbonyl)glycinate

: 870784-23-9
(2S,3S)-3-[(tert-butoxylcarbonyl)amino]-4-((3S)-3-fluoropyrrolidin-1-yl)-2-[4-(N-butoxycarboxylcyclohexyl)]-N,N-dimethyl-4-oxobutanamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: zinc(II) chloride; lithium hexamethyldisilazane / tetrahydrofuran; diethyl ether / 10 h / -78 - 20 °C

1.2: 8 h / 0 - 20 °C

2.1: methanol; sodium hydroxide; water / 3 h / 20 °C

3.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / DMF (N,N-dimethyl-formamide) / 16 h / 20 °C

4.1: potassium permanganate; sodium periodate; potassium carbonate / water; tert-butyl alcohol

5.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 16 h / 20 °C

6.1: triethylamine / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 24 h / 90 °C / 760.05 Torr

7.1: hydrogen; acetic acid / platinum(IV) oxide / 36 h / 20 °C / 2280.15 Torr

With methanol; sodium hydroxide; potassium permanganate; sodium periodate; water; hydrogen; potassium carbonate; benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; zinc(II) chloride; lithium hexamethyldisilazane; platinum(IV) oxide; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; DMF (N,N-dimethyl-formamide); diethyl ether; water; tert-butyl alcohol;