(S)-N-((S)-4-(3-fluoro-4-(trifluoromethoxy)phenyl)-3,4-dihydro-2H-pyrano[3,2-b]pyridin-4-yl)-2-methylpropane-2-sulfinamide

Base Information

Chemical Name:(S)-N-((S)-4-(3-fluoro-4-(trifluoromethoxy)phenyl)-3,4-dihydro-2H-pyrano[3,2-b]pyridin-4-yl)-2-methylpropane-2-sulfinamide
CAS No.:1561778-44-6
Molecular Formula:C₁₉H₂₀F₄N₂O₃S
Molecular Weight:432.439
Hs Code.:

Synonyms:(S)-N-((S)-4-(3-fluoro-4-(trifluoromethoxy)phenyl)-3,4-dihydro-2H-pyrano[3,2-b]pyridin-4-yl)-2-methylpropane-2-sulfinamide

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Chemical Property of (S)-N-((S)-4-(3-fluoro-4-(trifluoromethoxy)phenyl)-3,4-dihydro-2H-pyrano[3,2-b]pyridin-4-yl)-2-methylpropane-2-sulfinamide

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Technology Process of (S)-N-((S)-4-(3-fluoro-4-(trifluoromethoxy)phenyl)-3,4-dihydro-2H-pyrano[3,2-b]pyridin-4-yl)-2-methylpropane-2-sulfinamide

There total 5 articles about (S)-N-((S)-4-(3-fluoro-4-(trifluoromethoxy)phenyl)-3,4-dihydro-2H-pyrano[3,2-b]pyridin-4-yl)-2-methylpropane-2-sulfinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 105529-58-6
4-bromo-2-fluoro-1-(trifluoromethoxy)benzene

: 1561783-20-7
(S,E)-2-methyl-N-(2H-pyrano[3,2-b]pyridin-4(3H)-ylidene)propane-2-sulfinamide

: 1561778-44-6
(S)-N-((S)-4-(3-fluoro-4-(trifluoromethoxy)phenyl)-3,4-dihydro-2H-pyrano[3,2-b]pyridin-4-yl)-2-methylpropane-2-sulfinamide

Guidance literature:: 4-bromo-2-fluoro-1-(trifluoromethoxy)benzene; With iodine; magnesium; In 2-methyltetrahydrofuran; at 35 ℃; for 0.5h;

(S,E)-2-methyl-N-(2H-pyrano[3,2-b]pyridin-4(3H)-ylidene)propane-2-sulfinamide; In 2-methyltetrahydrofuran; Cooling with acetone-dry ice;

Reference yield:

: 405174-46-1
4-methylene-3,4-dihydro-2H-pyrano[3,2-b]pyridine

: 1561778-44-6
(S)-N-((S)-4-(3-fluoro-4-(trifluoromethoxy)phenyl)-3,4-dihydro-2H-pyrano[3,2-b]pyridin-4-yl)-2-methylpropane-2-sulfinamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydrogencarbonate; ozone / methanol; chloroform / 16 h / -78 °C

1.2: 12 h / -78 - 20 °C

2.1: titanium(IV) tetraethanolate / 2-methyltetrahydrofuran / 4 h / 20 °C

3.1: magnesium; iodine / 2-methyltetrahydrofuran / 0.5 h / 35 °C

3.2: Cooling with acetone-dry ice

With titanium(IV) tetraethanolate; iodine; sodium hydrogencarbonate; ozone; magnesium; In 2-methyltetrahydrofuran; methanol; chloroform; 3.1: |Grignard Reaction / 3.2: |Grignard Reaction;

Reference yield:

: 405174-45-0
2-bromo-3-(but-3-en-1-yloxy)pyridine

: 1561778-44-6
(S)-N-((S)-4-(3-fluoro-4-(trifluoromethoxy)phenyl)-3,4-dihydro-2H-pyrano[3,2-b]pyridin-4-yl)-2-methylpropane-2-sulfinamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: triphenylphosphine; palladium diacetate; potassium acetate; tetraethylammonium chloride / N,N-dimethyl-formamide / 16 h / 110 °C / Inert atmosphere

2.1: sodium hydrogencarbonate; ozone / methanol; chloroform / 16 h / -78 °C

2.2: 12 h / -78 - 20 °C

3.1: titanium(IV) tetraethanolate / 2-methyltetrahydrofuran / 4 h / 20 °C

4.1: magnesium; iodine / 2-methyltetrahydrofuran / 0.5 h / 35 °C

4.2: Cooling with acetone-dry ice

With titanium(IV) tetraethanolate; tetraethylammonium chloride; iodine; potassium acetate; palladium diacetate; sodium hydrogencarbonate; ozone; magnesium; triphenylphosphine; In 2-methyltetrahydrofuran; methanol; chloroform; N,N-dimethyl-formamide; 4.1: |Grignard Reaction / 4.2: |Grignard Reaction;