(S)-N-(4-(3-fluoro-4-(trifluoromethoxy)phenyl)-3,4-dihydro-2H-pyrano[3,2-b]pyridin-4-yl)benzenesulfonamide 2,2,2-trifluoroacetate

Base Information

• Chemical Name: (S)-N-(4-(3-fluoro-4-(trifluoromethoxy)phenyl)-3,4-dihydro-2H-pyrano[3,2-b]pyridin-4-yl)benzenesulfonamide 2,2,2-trifluoroacetate
• CAS No.: 1561765-64-7
• Molecular Formula: C₂HF₃O₂*C₂₁H₁₆F₄N₂O₄S
• Molecular Weight: 582.453
• Mol file: 1561765-64-7.mol

Synonyms:(S)-N-(4-(3-fluoro-4-(trifluoromethoxy)phenyl)-3,4-dihydro-2H-pyrano[3,2-b]pyridin-4-yl)benzenesulfonamide 2,2,2-trifluoroacetate

Chemical Property of (S)-N-(4-(3-fluoro-4-(trifluoromethoxy)phenyl)-3,4-dihydro-2H-pyrano[3,2-b]pyridin-4-yl)benzenesulfonamide 2,2,2-trifluoroacetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-N-(4-(3-fluoro-4-(trifluoromethoxy)phenyl)-3,4-dihydro-2H-pyrano[3,2-b]pyridin-4-yl)benzenesulfonamide 2,2,2-trifluoroacetate

There total 7 articles about (S)-N-(4-(3-fluoro-4-(trifluoromethoxy)phenyl)-3,4-dihydro-2H-pyrano[3,2-b]pyridin-4-yl)benzenesulfonamide 2,2,2-trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(S)-4-(3-fluoro-4-(trifluoromethoxy)phenyl)-3,4-dihydro-2H-pyrano[3,2-b]pyridin-4-amine hydrochloride (1561778-47-9) + benzenesulfonyl chloride (98-09-9) + trifluoroacetic acid (76-05-1) → (S)-N-(4-(3-fluoro-4-(trifluoromethoxy)phenyl)-3,4-dihydro-2H-pyrano[3,2-b]pyridin-4-yl)benzenesulfonamide 2,2,2-trifluoroacetate (1561765-64-7)

Guidance literature:

(S)-4-(3-fluoro-4-(trifluoromethoxy)phenyl)-3,4-dihydro-2H-pyrano[3,2-b]pyridin-4-amine hydrochloride; benzenesulfonyl chloride; With triethylamine; In dichloromethane; at 20 ℃; for 18h;

trifluoroacetic acid; In dichloromethane; water; acetonitrile;

Reference yield:

2-bromo-3-(but-3-en-1-yloxy)pyridine (405174-45-0) → (S)-N-(4-(3-fluoro-4-(trifluoromethoxy)phenyl)-3,4-dihydro-2H-pyrano[3,2-b]pyridin-4-yl)benzenesulfonamide 2,2,2-trifluoroacetate (1561765-64-7)

Guidance literature:

Multi-step reaction with 6 steps

1.1: triphenylphosphine; palladium diacetate; potassium acetate; tetraethylammonium chloride / N,N-dimethyl-formamide / 16 h / 110 °C / Inert atmosphere

2.1: sodium hydrogencarbonate; ozone / methanol; chloroform / 16 h / -78 °C

2.2: 12 h / -78 - 20 °C

3.1: titanium(IV) tetraethanolate / 2-methyltetrahydrofuran / 4 h / 20 °C

4.1: magnesium; iodine / 2-methyltetrahydrofuran / 0.5 h / 35 °C

4.2: Cooling with acetone-dry ice

5.1: hydrogenchloride / ethanol; 1,4-dioxane / 2 h / 20 °C

6.1: triethylamine / dichloromethane / 18 h / 20 °C

With hydrogenchloride; titanium(IV) tetraethanolate; tetraethylammonium chloride; iodine; potassium acetate; palladium diacetate; sodium hydrogencarbonate; ozone; magnesium; triethylamine; triphenylphosphine; In 2-methyltetrahydrofuran; 1,4-dioxane; methanol; ethanol; dichloromethane; chloroform; N,N-dimethyl-formamide; 4.1: |Grignard Reaction / 4.2: |Grignard Reaction;

Reference yield:

2,3-dihydro-4H-pyrano[3,2-b]pyridine-4-one (405174-48-3) → (S)-N-(4-(3-fluoro-4-(trifluoromethoxy)phenyl)-3,4-dihydro-2H-pyrano[3,2-b]pyridin-4-yl)benzenesulfonamide 2,2,2-trifluoroacetate (1561765-64-7)

Guidance literature:

Multi-step reaction with 4 steps

1.1: titanium(IV) tetraethanolate / 2-methyltetrahydrofuran / 4 h / 20 °C

2.1: magnesium; iodine / 2-methyltetrahydrofuran / 0.5 h / 35 °C

2.2: Cooling with acetone-dry ice

3.1: hydrogenchloride / ethanol; 1,4-dioxane / 2 h / 20 °C

4.1: triethylamine / dichloromethane / 18 h / 20 °C

With hydrogenchloride; titanium(IV) tetraethanolate; iodine; magnesium; triethylamine; In 2-methyltetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; 2.1: |Grignard Reaction / 2.2: |Grignard Reaction;

upstream raw materials:

2-bromo-pyridin-3-ol

2-bromo-3-(but-3-en-1-yloxy)pyridine

4-methylene-3,4-dihydro-2H-pyrano[3,2-b]pyridine

2,3-dihydro-4H-pyrano[3,2-b]pyridine-4-one

Refernces