(S)-3-(N-tert-butoxycarbonyl-2-methylamino-3-phenylpropyl)-1-(2,6-difluorobenzyl)-5-(2-fluoro-3-methoxyphenyl)-6-methyluracil

Base Information

Chemical Name:(S)-3-(N-tert-butoxycarbonyl-2-methylamino-3-phenylpropyl)-1-(2,6-difluorobenzyl)-5-(2-fluoro-3-methoxyphenyl)-6-methyluracil
CAS No.:732282-65-4
Molecular Formula:C₃₄H₃₆F₃N₃O₅
Molecular Weight:623.672
Hs Code.:

Synonyms:(S)-3-(N-tert-butoxycarbonyl-2-methylamino-3-phenylpropyl)-1-(2,6-difluorobenzyl)-5-(2-fluoro-3-methoxyphenyl)-6-methyluracil

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Chemical Property of (S)-3-(N-tert-butoxycarbonyl-2-methylamino-3-phenylpropyl)-1-(2,6-difluorobenzyl)-5-(2-fluoro-3-methoxyphenyl)-6-methyluracil

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Technology Process of (S)-3-(N-tert-butoxycarbonyl-2-methylamino-3-phenylpropyl)-1-(2,6-difluorobenzyl)-5-(2-fluoro-3-methoxyphenyl)-6-methyluracil

There total 4 articles about (S)-3-(N-tert-butoxycarbonyl-2-methylamino-3-phenylpropyl)-1-(2,6-difluorobenzyl)-5-(2-fluoro-3-methoxyphenyl)-6-methyluracil which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 352303-67-4
(2-fluoro-3-methoxyphenyl)boronic acid

: 732282-64-3
(S)-5-bromo-3-(N-tert-butoxycarbonyl-2-methylamino-3-phenylpropyl)-1-(2,6-difluorobenzyl)-6-methyluracil

: 732282-65-4
(S)-3-(N-tert-butoxycarbonyl-2-methylamino-3-phenylpropyl)-1-(2,6-difluorobenzyl)-5-(2-fluoro-3-methoxyphenyl)-6-methyluracil

Guidance literature:: With barium dihydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,2-dimethoxyethane; toluene; at 90 ℃; for 40h;
DOI:10.1021/jm049791w

Reference yield:

: 264128-49-6
(S)-tert-butyl (1-hydroxy-3-phenylpropan-2-yl)(methyl)carbamate

: 732282-65-4
(S)-3-(N-tert-butoxycarbonyl-2-methylamino-3-phenylpropyl)-1-(2,6-difluorobenzyl)-5-(2-fluoro-3-methoxyphenyl)-6-methyluracil

Guidance literature:: Multi-step reaction with 2 steps

1: PPh₃; diethyl azodicarboxylate / tetrahydrofuran / 20 °C

2: aq. Ba(OH)2; tetrakis(triphenylphosphine)palladium / benzene; ethanol; 1,2-dimethoxy-ethane / 80 °C

With barium dihydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; 1,2-dimethoxyethane; ethanol; benzene; 1: Mitsunobu reaction / 2: Suzuki coupling;
DOI:10.1021/jm049218c

Reference yield:

: 352303-66-3
5-bromo-1-(2,6-difluoro-benzyl)-6-methyl-1H-pyrimidine-2,4-dione

: 732282-65-4
(S)-3-(N-tert-butoxycarbonyl-2-methylamino-3-phenylpropyl)-1-(2,6-difluorobenzyl)-5-(2-fluoro-3-methoxyphenyl)-6-methyluracil

Guidance literature:: Multi-step reaction with 2 steps

1: PPh₃; diethyl azodicarboxylate / tetrahydrofuran / 20 °C

2: aq. Ba(OH)2; tetrakis(triphenylphosphine)palladium / benzene; ethanol; 1,2-dimethoxy-ethane / 80 °C

With barium dihydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; 1,2-dimethoxyethane; ethanol; benzene; 1: Mitsunobu reaction / 2: Suzuki coupling;
DOI:10.1021/jm049218c