1-<(2-amino-4-hydroxy-5-nitropyrimidin-6-yl)amino>-4-methyl-5-(p-carbomethoxyphenyl)pentan-2-one

Base Information

Chemical Name:1-<(2-amino-4-hydroxy-5-nitropyrimidin-6-yl)amino>-4-methyl-5-(p-carbomethoxyphenyl)pentan-2-one
CAS No.:119770-52-4
Molecular Formula:C₁₈H₂₁N₅O₆
Molecular Weight:403.395
Hs Code.:

Synonyms:1-<(2-amino-4-hydroxy-5-nitropyrimidin-6-yl)amino>-4-methyl-5-(p-carbomethoxyphenyl)pentan-2-one

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Chemical Property of 1-<(2-amino-4-hydroxy-5-nitropyrimidin-6-yl)amino>-4-methyl-5-(p-carbomethoxyphenyl)pentan-2-one

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Technology Process of 1-<(2-amino-4-hydroxy-5-nitropyrimidin-6-yl)amino>-4-methyl-5-(p-carbomethoxyphenyl)pentan-2-one

There total 8 articles about 1-<(2-amino-4-hydroxy-5-nitropyrimidin-6-yl)amino>-4-methyl-5-(p-carbomethoxyphenyl)pentan-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 119770-50-2
1-<(2-amino-4-hydroxy-5-nitropyrimidin-6-yl)amino>-5-(p-carbomethoxyphenyl)-4-methyl-2-pentanone oxime

: 119770-52-4
1-<(2-amino-4-hydroxy-5-nitropyrimidin-6-yl)amino>-4-methyl-5-(p-carbomethoxyphenyl)pentan-2-one

Guidance literature:: With hydrogenchloride; trifluoroacetic acid; at 60 ℃; Yield given;
DOI:10.1021/jm00126a022

Reference yield:

: 106918-32-5
4-carbomethoxyphenylacetaldehyde

: 119770-52-4
1-<(2-amino-4-hydroxy-5-nitropyrimidin-6-yl)amino>-4-methyl-5-(p-carbomethoxyphenyl)pentan-2-one

Guidance literature:: Multi-step reaction with 6 steps

1: 56 percent / CH₂Cl₂ / 40 h / Ambient temperature

2: 41 percent / CuBr / tetrahydrofuran / a) -25 deg C, 2 h, b) r.t., 12 h

3: 99 percent / hydroxylamine hydrochloride, pyridine / methanol / 1 h / Heating

4: 83 percent / hydrazine / methanol / 48 h

5: 75 percent / methylmorpholine / methanol / 3 h / Heating

6: 1N HCl, TFA / 60 °C

With 2-methylmorpholine; pyridine; hydrogenchloride; hydroxylamine hydrochloride; trifluoroacetic acid; copper(I) bromide; hydrazine; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1021/jm00126a022

Reference yield:

: 119770-48-8
1-amino-5-(p-carbomethoxyphenyl)-4-methyl-2-pentanone oxime

: 119770-52-4
1-<(2-amino-4-hydroxy-5-nitropyrimidin-6-yl)amino>-4-methyl-5-(p-carbomethoxyphenyl)pentan-2-one

Guidance literature:: Multi-step reaction with 2 steps

1: 75 percent / methylmorpholine / methanol / 3 h / Heating

2: 1N HCl, TFA / 60 °C

With 2-methylmorpholine; hydrogenchloride; trifluoroacetic acid; In methanol;
DOI:10.1021/jm00126a022