(2E,4E)-methyl 6-(4-methyl-N-(2-oxoethyl)phenylsulfonamido)hexa-2,4-dienoate

Base Information

Chemical Name:(2E,4E)-methyl 6-(4-methyl-N-(2-oxoethyl)phenylsulfonamido)hexa-2,4-dienoate
CAS No.:1579963-67-9
Molecular Formula:C₁₆H₁₉NO₅S
Molecular Weight:337.397
Hs Code.:

Synonyms:(2E,4E)-methyl 6-(4-methyl-N-(2-oxoethyl)phenylsulfonamido)hexa-2,4-dienoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2E,4E)-methyl 6-(4-methyl-N-(2-oxoethyl)phenylsulfonamido)hexa-2,4-dienoate

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Technology Process of (2E,4E)-methyl 6-(4-methyl-N-(2-oxoethyl)phenylsulfonamido)hexa-2,4-dienoate

There total 4 articles about (2E,4E)-methyl 6-(4-methyl-N-(2-oxoethyl)phenylsulfonamido)hexa-2,4-dienoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 1579963-97-5
(2E,4E)-methyl 6-(N-(2-hydroxyethyl)-4-methylphenylsulfonamido)hexa-2,4-dienoate

: 1579963-67-9
(2E,4E)-methyl 6-(4-methyl-N-(2-oxoethyl)phenylsulfonamido)hexa-2,4-dienoate

Guidance literature:: With 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; In dimethyl sulfoxide; at 20 ℃; for 4h; Inert atmosphere;
DOI:10.1002/chem.201303435

Reference yield:

: 14316-14-4
N-(2-hydroxy-ethyl)-4-methyl-benzenesulfonamide

: 1579963-67-9
(2E,4E)-methyl 6-(4-methyl-N-(2-oxoethyl)phenylsulfonamido)hexa-2,4-dienoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: 1H-imidazole / dichloromethane / 22 h / 20 °C / Inert atmosphere

2.1: sodium hydride / tetrahydrofuran; mineral oil / 1.5 h / 0 - 20 °C / Inert atmosphere

2.2: 20 h / 20 °C / Inert atmosphere

2.3: 18 h / 20 °C / Inert atmosphere

3.1: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / dimethyl sulfoxide / 4 h / 20 °C / Inert atmosphere

With 1H-imidazole; sodium hydride; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; In tetrahydrofuran; dichloromethane; dimethyl sulfoxide; mineral oil;
DOI:10.1002/chem.201303435

Reference yield:

: 202974-92-3
N-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-4-methyl-benzenesulfonamide

: 1579963-67-9
(2E,4E)-methyl 6-(4-methyl-N-(2-oxoethyl)phenylsulfonamido)hexa-2,4-dienoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 1.5 h / 0 - 20 °C / Inert atmosphere

1.2: 20 h / 20 °C / Inert atmosphere

1.3: 18 h / 20 °C / Inert atmosphere

2.1: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / dimethyl sulfoxide / 4 h / 20 °C / Inert atmosphere

With sodium hydride; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; In tetrahydrofuran; dimethyl sulfoxide; mineral oil;
DOI:10.1002/chem.201303435