(2E,4E)-methyl 6-(N-(2-hydroxyethyl)-4-methylphenylsulfonamido)hexa-2,4-dienoate

Base Information

Chemical Name:(2E,4E)-methyl 6-(N-(2-hydroxyethyl)-4-methylphenylsulfonamido)hexa-2,4-dienoate
CAS No.:1579963-97-5
Molecular Formula:C₁₆H₂₁NO₅S
Molecular Weight:339.412
Hs Code.:

Synonyms:(2E,4E)-methyl 6-(N-(2-hydroxyethyl)-4-methylphenylsulfonamido)hexa-2,4-dienoate

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Chemical Property of (2E,4E)-methyl 6-(N-(2-hydroxyethyl)-4-methylphenylsulfonamido)hexa-2,4-dienoate

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Technology Process of (2E,4E)-methyl 6-(N-(2-hydroxyethyl)-4-methylphenylsulfonamido)hexa-2,4-dienoate

There total 3 articles about (2E,4E)-methyl 6-(N-(2-hydroxyethyl)-4-methylphenylsulfonamido)hexa-2,4-dienoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

: 51010-88-9
methyl (2E,4E)-6-bromo-2,4-hexadienoate

: 202974-92-3
N-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-4-methyl-benzenesulfonamide

: 14316-14-4
N-(2-hydroxy-ethyl)-4-methyl-benzenesulfonamide

: 1579963-97-5
(2E,4E)-methyl 6-(N-(2-hydroxyethyl)-4-methylphenylsulfonamido)hexa-2,4-dienoate

Guidance literature:: N-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-4-methyl-benzenesulfonamide; With sodium hydride; In tetrahydrofuran; mineral oil; at 0 - 20 ℃; for 1.5h; Inert atmosphere;

methyl (2E,4E)-6-bromo-2,4-hexadienoate; In tetrahydrofuran; mineral oil; at 20 ℃; for 20h; Inert atmosphere;

With acetic acid; In tetrahydrofuran; water; at 20 ℃; for 18h; Inert atmosphere;
DOI:10.1002/chem.201303435

Reference yield:

: 14316-14-4
N-(2-hydroxy-ethyl)-4-methyl-benzenesulfonamide

: 1579963-97-5
(2E,4E)-methyl 6-(N-(2-hydroxyethyl)-4-methylphenylsulfonamido)hexa-2,4-dienoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: 1H-imidazole / dichloromethane / 22 h / 20 °C / Inert atmosphere

2.1: sodium hydride / tetrahydrofuran; mineral oil / 1.5 h / 0 - 20 °C / Inert atmosphere

2.2: 20 h / 20 °C / Inert atmosphere

2.3: 18 h / 20 °C / Inert atmosphere

With 1H-imidazole; sodium hydride; In tetrahydrofuran; dichloromethane; mineral oil;
DOI:10.1002/chem.201303435

Reference yield:

: 98-59-9
p-toluenesulfonyl chloride

: 1579963-97-5
(2E,4E)-methyl 6-(N-(2-hydroxyethyl)-4-methylphenylsulfonamido)hexa-2,4-dienoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine / dichloromethane / 18 h / 0 - 20 °C / Inert atmosphere

2.1: 1H-imidazole / dichloromethane / 22 h / 20 °C / Inert atmosphere

3.1: sodium hydride / tetrahydrofuran; mineral oil / 1.5 h / 0 - 20 °C / Inert atmosphere

3.2: 20 h / 20 °C / Inert atmosphere

3.3: 18 h / 20 °C / Inert atmosphere

With 1H-imidazole; sodium hydride; triethylamine; In tetrahydrofuran; dichloromethane; mineral oil;
DOI:10.1002/chem.201303435