2-phenoxy-5-(2-trimethylsilanyl-ethoxymethyl)-5H-pyrrolo[2,3-b]pyrazine-7-carbaldehyde

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Chemical Name:2-phenoxy-5-(2-trimethylsilanyl-ethoxymethyl)-5H-pyrrolo[2,3-b]pyrazine-7-carbaldehyde
CAS No.:1334675-22-7
Molecular Formula:C₁₉H₂₃N₃O₃Si
Molecular Weight:369.495
Hs Code.:

Synonyms:2-phenoxy-5-(2-trimethylsilanyl-ethoxymethyl)-5H-pyrrolo[2,3-b]pyrazine-7-carbaldehyde

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Chemical Property of 2-phenoxy-5-(2-trimethylsilanyl-ethoxymethyl)-5H-pyrrolo[2,3-b]pyrazine-7-carbaldehyde

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Technology Process of 2-phenoxy-5-(2-trimethylsilanyl-ethoxymethyl)-5H-pyrrolo[2,3-b]pyrazine-7-carbaldehyde

There total 7 articles about 2-phenoxy-5-(2-trimethylsilanyl-ethoxymethyl)-5H-pyrrolo[2,3-b]pyrazine-7-carbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

: 1185428-34-5
2-bromo-5-(2-trimethylsilanyl-ethoxymethyl)-5H-pyrrolo-[2,3-b]pyrazine-7-carbaldehyde

: 108-95-2,27073-41-2
phenol

: 1334675-22-7
2-phenoxy-5-(2-trimethylsilanyl-ethoxymethyl)-5H-pyrrolo[2,3-b]pyrazine-7-carbaldehyde

Guidance literature:: With potassium phosphate; 2'-(di-tert-butylphosphanyl)-N,N-dimethyl-[1,1'-biphenyl]-2-amine; palladium diacetate; In toluene; at 150 ℃; Inert atmosphere; sealed tube;

Reference yield:

: 875781-43-4
2-bromo-5H-pyrrolo[2,3-b]pyrazine

: 1334675-22-7
2-phenoxy-5-(2-trimethylsilanyl-ethoxymethyl)-5H-pyrrolo[2,3-b]pyrazine-7-carbaldehyde

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydroxide / 1,4-dioxane; water / 20 °C

2.1: sodium hydroxide; water / tetrahydrofuran

2.2: pH 4

3.1: Jones reagent / water; acetone / 0.25 h

4.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0 - 20 °C

4.2: 0 - 20 °C

5.1: potassium phosphate; 2'-(di-tert-butylphosphanyl)-N,N-dimethyl-[1,1'-biphenyl]-2-amine / palladium diacetate / toluene / 150 °C / Inert atmosphere; sealed tube

With potassium phosphate; Jones reagent; water; sodium hydride; sodium hydroxide; 2'-(di-tert-butylphosphanyl)-N,N-dimethyl-[1,1'-biphenyl]-2-amine; palladium diacetate; In tetrahydrofuran; 1,4-dioxane; water; N,N-dimethyl-formamide; acetone; toluene; mineral oil;

Reference yield:

: 1185428-32-3
2-bromo-5H-pyrrolo[2,3-b]pyrazine-7-carbaldehyde

: 1334675-22-7
2-phenoxy-5-(2-trimethylsilanyl-ethoxymethyl)-5H-pyrrolo[2,3-b]pyrazine-7-carbaldehyde

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0 - 20 °C

1.2: 0 - 20 °C

2.1: potassium phosphate; 2'-(di-tert-butylphosphanyl)-N,N-dimethyl-[1,1'-biphenyl]-2-amine / palladium diacetate / toluene / 150 °C / Inert atmosphere; sealed tube

With potassium phosphate; sodium hydride; 2'-(di-tert-butylphosphanyl)-N,N-dimethyl-[1,1'-biphenyl]-2-amine; palladium diacetate; In N,N-dimethyl-formamide; toluene; mineral oil;