Technology Process of 2-phenoxy-5-(2-trimethylsilanyl-ethoxymethyl)-5H-pyrrolo[2,3-b]pyrazine-7-carbaldehyde
There total 7 articles about 2-phenoxy-5-(2-trimethylsilanyl-ethoxymethyl)-5H-pyrrolo[2,3-b]pyrazine-7-carbaldehyde which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
potassium phosphate; 2'-(di-tert-butylphosphanyl)-N,N-dimethyl-[1,1'-biphenyl]-2-amine;
palladium diacetate;
In
toluene;
at 150 ℃;
Inert atmosphere;
sealed tube;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: sodium hydroxide / 1,4-dioxane; water / 20 °C
2.1: sodium hydroxide; water / tetrahydrofuran
2.2: pH 4
3.1: Jones reagent / water; acetone / 0.25 h
4.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0 - 20 °C
4.2: 0 - 20 °C
5.1: potassium phosphate; 2'-(di-tert-butylphosphanyl)-N,N-dimethyl-[1,1'-biphenyl]-2-amine / palladium diacetate / toluene / 150 °C / Inert atmosphere; sealed tube
With
potassium phosphate; Jones reagent; water; sodium hydride; sodium hydroxide; 2'-(di-tert-butylphosphanyl)-N,N-dimethyl-[1,1'-biphenyl]-2-amine;
palladium diacetate;
In
tetrahydrofuran; 1,4-dioxane; water; N,N-dimethyl-formamide; acetone; toluene; mineral oil;
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0 - 20 °C
1.2: 0 - 20 °C
2.1: potassium phosphate; 2'-(di-tert-butylphosphanyl)-N,N-dimethyl-[1,1'-biphenyl]-2-amine / palladium diacetate / toluene / 150 °C / Inert atmosphere; sealed tube
With
potassium phosphate; sodium hydride; 2'-(di-tert-butylphosphanyl)-N,N-dimethyl-[1,1'-biphenyl]-2-amine;
palladium diacetate;
In
N,N-dimethyl-formamide; toluene; mineral oil;