propane-2-sulfonic acid ((3S,4S)-4-biphenyl-4-yl-1-methyl-piperidin-3-yl)-amide

Base Information

• Chemical Name: propane-2-sulfonic acid ((3S,4S)-4-biphenyl-4-yl-1-methyl-piperidin-3-yl)-amide
• CAS No.: 1068519-29-8
• Molecular Formula: C₂₁H₂₈N₂O₂S
• Molecular Weight: 372.532
• Mol file: 1068519-29-8.mol

Synonyms:propane-2-sulfonic acid ((3S,4S)-4-biphenyl-4-yl-1-methyl-piperidin-3-yl)-amide

Chemical Property of propane-2-sulfonic acid ((3S,4S)-4-biphenyl-4-yl-1-methyl-piperidin-3-yl)-amide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of propane-2-sulfonic acid ((3S,4S)-4-biphenyl-4-yl-1-methyl-piperidin-3-yl)-amide

There total 12 articles about propane-2-sulfonic acid ((3S,4S)-4-biphenyl-4-yl-1-methyl-piperidin-3-yl)-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C9H14O3NC6H5 (41276-30-6) → propane-2-sulfonic acid ((3R,4R)-4-biphenyl-4-yl-1-methyl-piperidin-3-yl)-amide (1068519-26-5) + propane-2-sulfonic acid ((3S,4S)-4-biphenyl-4-yl-1-methyl-piperidin-3-yl)-amide (1068519-29-8)

Guidance literature:

Multi-step reaction with 11 steps

1.1: sodium hydride / diethyl ether / 1 h / 20 °C

2.1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / tetrahydrofuran / 20 - 60 °C

3.1: hydrogen; acetic acid / palladium 10% on activated carbon / ethanol / 60 °C / 2585.81 Torr

4.1: potassium carbonate / tetrahydrofuran / 20 °C

5.1: sodium ethanolate / ethanol / 4 h / Heating / reflux

6.1: methanol; potassium hydroxide; water / Heating / reflux

6.2: pH ~ 2

7.1: diphenyl phosphoryl azide; triethylamine / toluene / 3.5 h / 80 °C

7.2: 20 °C

8.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / dichloromethane / 0 - 20 °C

9.1: hydrogenchloride; methanol / 1,4-dioxane / 1 h / 20 °C

10.1: sodium tris(acetoxy)borohydride / water; 1,2-dichloro-ethane / 2 h

11.1: ethanol; n-heptane

With hydrogenchloride; methanol; potassium hydroxide; diphenyl phosphoryl azide; water; hydrogen; sodium ethanolate; sodium tris(acetoxy)borohydride; sodium hydride; potassium carbonate; acetic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium 10% on activated carbon; In tetrahydrofuran; 1,4-dioxane; diethyl ether; ethanol; n-heptane; dichloromethane; water; 1,2-dichloro-ethane; toluene;

Reference yield:

ethyl 4-([1,1'-biphenyl]-4-yl)-1-benzyl-1,2,5,6-tetrahydropyridine-3-carboxylate (1068521-93-6) → propane-2-sulfonic acid ((3R,4R)-4-biphenyl-4-yl-1-methyl-piperidin-3-yl)-amide (1068519-26-5) + propane-2-sulfonic acid ((3S,4S)-4-biphenyl-4-yl-1-methyl-piperidin-3-yl)-amide (1068519-29-8)

Guidance literature:

Multi-step reaction with 9 steps

1.1: hydrogen; acetic acid / palladium 10% on activated carbon / ethanol / 60 °C / 2585.81 Torr

2.1: potassium carbonate / tetrahydrofuran / 20 °C

3.1: sodium ethanolate / ethanol / 4 h / Heating / reflux

4.1: methanol; potassium hydroxide; water / Heating / reflux

4.2: pH ~ 2

5.1: diphenyl phosphoryl azide; triethylamine / toluene / 3.5 h / 80 °C

5.2: 20 °C

6.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / dichloromethane / 0 - 20 °C

7.1: hydrogenchloride; methanol / 1,4-dioxane / 1 h / 20 °C

8.1: sodium tris(acetoxy)borohydride / water; 1,2-dichloro-ethane / 2 h

9.1: ethanol; n-heptane

With hydrogenchloride; methanol; potassium hydroxide; diphenyl phosphoryl azide; water; hydrogen; sodium ethanolate; sodium tris(acetoxy)borohydride; potassium carbonate; acetic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; palladium 10% on activated carbon; In tetrahydrofuran; 1,4-dioxane; ethanol; n-heptane; dichloromethane; water; 1,2-dichloro-ethane; toluene;

Reference yield:

ethyl 1-benzyl-4-oxopiperidine-3-carboxylate hydrochloride (1454-53-1) → propane-2-sulfonic acid ((3R,4R)-4-biphenyl-4-yl-1-methyl-piperidin-3-yl)-amide (1068519-26-5) + propane-2-sulfonic acid ((3S,4S)-4-biphenyl-4-yl-1-methyl-piperidin-3-yl)-amide (1068519-29-8)

Guidance literature:

Multi-step reaction with 12 steps

1.1: sodium carbonate / water / 1 h

2.1: sodium hydride / diethyl ether / 1 h / 20 °C

3.1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / tetrahydrofuran / 20 - 60 °C

4.1: hydrogen; acetic acid / palladium 10% on activated carbon / ethanol / 60 °C / 2585.81 Torr

5.1: potassium carbonate / tetrahydrofuran / 20 °C

6.1: sodium ethanolate / ethanol / 4 h / Heating / reflux

7.1: methanol; potassium hydroxide; water / Heating / reflux

7.2: pH ~ 2

8.1: diphenyl phosphoryl azide; triethylamine / toluene / 3.5 h / 80 °C

8.2: 20 °C

9.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / dichloromethane / 0 - 20 °C

10.1: hydrogenchloride; methanol / 1,4-dioxane / 1 h / 20 °C

11.1: sodium tris(acetoxy)borohydride / water; 1,2-dichloro-ethane / 2 h

12.1: ethanol; n-heptane

With hydrogenchloride; methanol; potassium hydroxide; diphenyl phosphoryl azide; water; hydrogen; sodium ethanolate; sodium tris(acetoxy)borohydride; sodium hydride; sodium carbonate; potassium carbonate; acetic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium 10% on activated carbon; In tetrahydrofuran; 1,4-dioxane; diethyl ether; ethanol; n-heptane; dichloromethane; water; 1,2-dichloro-ethane; toluene;

upstream raw materials:

ethyl 4-([1,1'-biphenyl]-4-yl)-1-benzyl-1,2,5,6-tetrahydropyridine-3-carboxylate

C₉H₁₄O₃NC₆H₅

ethyl 1-benzyl-4-oxopiperidine-3-carboxylate hydrochloride

ethyl 1-benzyl-4-(trifluoromethylsulfonyloxy)-1,2,5,6-tetrahydropyridine-3-carboxylate