2-amino-6-(3-iodobenzyloxy)-9-(octyltetra-O-benzoyl-β-D-glucopyranoside)purine

Base Information

Chemical Name:2-amino-6-(3-iodobenzyloxy)-9-(octyltetra-O-benzoyl-β-D-glucopyranoside)purine
CAS No.:875584-35-3
Molecular Formula:C₅₄H₅₂IN₅O₁₁
Molecular Weight:1073.94
Hs Code.:

Synonyms:2-amino-6-(3-iodobenzyloxy)-9-(octyltetra-O-benzoyl-β-D-glucopyranoside)purine

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Chemical Property of 2-amino-6-(3-iodobenzyloxy)-9-(octyltetra-O-benzoyl-β-D-glucopyranoside)purine

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Technology Process of 2-amino-6-(3-iodobenzyloxy)-9-(octyltetra-O-benzoyl-β-D-glucopyranoside)purine

There total 6 articles about 2-amino-6-(3-iodobenzyloxy)-9-(octyltetra-O-benzoyl-β-D-glucopyranoside)purine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 15.0%

: 382607-65-0
8-bromooctyl-2,3,4,6-tetra-O-benzoyl-β-D-glucopyranoside

: 321195-47-5
2-amino-6-(3-iodobenzyloxy)-9H-purine

: 875584-35-3
2-amino-6-(3-iodobenzyloxy)-9-(octyltetra-O-benzoyl-β-D-glucopyranoside)purine

Guidance literature:: 2-amino-6-(3-iodobenzyloxy)-9H-purine; With 4 A molecular sieve; lithium hydride; In N,N-dimethyl-formamide; at 20 ℃; for 1h;

8-bromooctyl-2,3,4,6-tetra-O-benzoyl-β-D-glucopyranoside; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 23h;
DOI:10.1021/jm050588q

Reference yield:

: 14218-11-2
2,3,4,6-tetra-O-benzoylglucosyl bromide

: 875584-35-3
2-amino-6-(3-iodobenzyloxy)-9-(octyltetra-O-benzoyl-β-D-glucopyranoside)purine

Guidance literature:: Multi-step reaction with 4 steps

1.1: 76 percent / aq. NaI / acetone / 80 h / 20 °C

2.1: 95 percent / DBU / CH₂Cl₂ / 2 h / 0 °C

3.1: 57 percent / BF₃*Et₂O / CH₂Cl₂ / 4 h / 20 °C

4.1: LiH; 4 Angstroem molecular sieves / dimethylformamide / 1 h / 20 °C

4.2: 15 percent / dimethylformamide / 23 h / 0 - 20 °C

With 4 A molecular sieve; boron trifluoride diethyl etherate; lithium hydride; 1,8-diazabicyclo[5.4.0]undec-7-ene; sodium iodide; In dichloromethane; N,N-dimethyl-formamide; acetone;
DOI:10.1021/jm050588q

Reference yield:

: 57455-06-8
3-iodobenzylalcohol

: 875584-35-3
2-amino-6-(3-iodobenzyloxy)-9-(octyltetra-O-benzoyl-β-D-glucopyranoside)purine

Guidance literature:: Multi-step reaction with 2 steps

1.1: NaH / dimethylsulfoxide / 1 h / 20 °C

1.2: 97 percent / dimethylsulfoxide / 73 h / 20 °C

2.1: LiH; 4 Angstroem molecular sieves / dimethylformamide / 1 h / 20 °C

2.2: 15 percent / dimethylformamide / 23 h / 0 - 20 °C

With 4 A molecular sieve; lithium hydride; sodium hydride; In dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1021/jm050588q