benzyl (1R,2R,4S)-4-(tert-butoxycarbonyl(methyl)amino)-2-(2,4-difluorophenyl)-cyclopentanecarboxylate

Base Information

• Chemical Name: benzyl (1R,2R,4S)-4-(tert-butoxycarbonyl(methyl)amino)-2-(2,4-difluorophenyl)-cyclopentanecarboxylate
• CAS No.: 934989-24-9
• Molecular Formula: C₂₅H₂₉F₂NO₄
• Molecular Weight: 445.506

Synonyms:benzyl (1R,2R,4S)-4-(tert-butoxycarbonyl(methyl)amino)-2-(2,4-difluorophenyl)-cyclopentanecarboxylate

Chemical Property of benzyl (1R,2R,4S)-4-(tert-butoxycarbonyl(methyl)amino)-2-(2,4-difluorophenyl)-cyclopentanecarboxylate

Chemical Property:

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Technology Process of benzyl (1R,2R,4S)-4-(tert-butoxycarbonyl(methyl)amino)-2-(2,4-difluorophenyl)-cyclopentanecarboxylate

There total 2 articles about benzyl (1R,2R,4S)-4-(tert-butoxycarbonyl(methyl)amino)-2-(2,4-difluorophenyl)-cyclopentanecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C25H29F2NO4 (934989-23-8) → benzyl (1R,2R,4S)-4-(tert-butoxycarbonyl(methyl)amino)-2-(2,4-difluorophenyl)-cyclopentanecarboxylate (934989-24-9) + C25H29F2NO4 (934989-25-0)

Guidance literature:

Resolution of racemate;

Reference yield:

C20H21F2NO2 (1015485-77-4) + di-tert-butyl dicarbonate (24424-99-5) → benzyl (1R,2R,4S)-4-(tert-butoxycarbonyl(methyl)amino)-2-(2,4-difluorophenyl)-cyclopentanecarboxylate (934989-24-9) + C25H29F2NO4 (934989-25-0)

Guidance literature:

With triethylamine; sodium hydroxide; In dichloromethane; water;

DOI:10.1016/j.bmcl.2010.09.049

Reference yield:

benzyl (1R,2R,4S)-4-(tert-butoxycarbonyl(methyl)amino)-2-(2,4-difluorophenyl)-cyclopentanecarboxylate (934989-24-9) → (1R,2R,4S)-4-(tert-butoxycarbonyl(methyl)amino)-2-(2,4-difluorophenyl)cyclopentane-carboxylic acid (1352246-47-9)

Guidance literature:

With hydrogen; 5%-palladium/activated carbon; In tetrahydrofuran; at 20 ℃; for 24h; under 760.051 Torr;

upstream raw materials:

C₂₅H₂₉F₂NO₄

C₂₀H₂₁F₂NO₂

di-tert-butyl dicarbonate

Downstream raw materials:

(1R,2R,4S)-4-(tert-butoxycarbonyl(methyl)amino)-2-(2,4-difluorophenyl)cyclopentane-carboxylic acid

tert-butyl N-[(1S,3R,4R)-3-[4-[2-(4-chloro-3-methyl-phenyl)-5-methyl-1,2,4-triazol-3-yl]piperidine-carbonyl]-4-(2,4-difluorophenyl)cyclopentyl]-N-methyl-carbamate

[4-[2-[4-chloro-3-methyl-phenyl]-5-methyl-1,2,4-triazol-3-yl]-1-piperidyl]-[(1R,2R)-2-(2,4-difluorophenyl)-4-methylamino-cyclopentyl]methanone trifluoroacetate

[4-[2-(4-chloro-3-methyl-phenyl)-5-methyl-1,2,4-triazol-3-yl]-1-piperidyl]-[(1R,2R,4S)-2-(2,4-difluorophenyl)-4-(methyl(3,3,3-trifluoropropyl)amino)cyclopentyl]methanone trifluoroacetate

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