[4-[2-[4-chloro-3-methyl-phenyl]-5-methyl-1,2,4-triazol-3-yl]-1-piperidyl]-[(1R,2R)-2-(2,4-difluorophenyl)-4-methylamino-cyclopentyl]methanone trifluoroacetate

Base Information

Chemical Name:[4-[2-[4-chloro-3-methyl-phenyl]-5-methyl-1,2,4-triazol-3-yl]-1-piperidyl]-[(1R,2R)-2-(2,4-difluorophenyl)-4-methylamino-cyclopentyl]methanone trifluoroacetate
CAS No.:1352244-97-3
Molecular Formula:C₂HF₃O₂*C₂₈H₃₂ClF₂N₅O
Molecular Weight:642.069
Hs Code.:

[4-[2-[4-chloro-3-methyl-phenyl]-5-methyl-1,2,4-triazol-3-yl]-1-piperidyl]-[(1R,2R)-2-(2,4-difluorophenyl)-4-methylamino-cyclopentyl]methanone trifluoroacetate

Synonyms:[4-[2-[4-chloro-3-methyl-phenyl]-5-methyl-1,2,4-triazol-3-yl]-1-piperidyl]-[(1R,2R)-2-(2,4-difluorophenyl)-4-methylamino-cyclopentyl]methanone trifluoroacetate

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Chemical Property of [4-[2-[4-chloro-3-methyl-phenyl]-5-methyl-1,2,4-triazol-3-yl]-1-piperidyl]-[(1R,2R)-2-(2,4-difluorophenyl)-4-methylamino-cyclopentyl]methanone trifluoroacetate

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Technology Process of [4-[2-[4-chloro-3-methyl-phenyl]-5-methyl-1,2,4-triazol-3-yl]-1-piperidyl]-[(1R,2R)-2-(2,4-difluorophenyl)-4-methylamino-cyclopentyl]methanone trifluoroacetate

There total 7 articles about [4-[2-[4-chloro-3-methyl-phenyl]-5-methyl-1,2,4-triazol-3-yl]-1-piperidyl]-[(1R,2R)-2-(2,4-difluorophenyl)-4-methylamino-cyclopentyl]methanone trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1352246-48-0
tert-butyl N-[(1S,3R,4R)-3-[4-[2-(4-chloro-3-methyl-phenyl)-5-methyl-1,2,4-triazol-3-yl]piperidine-carbonyl]-4-(2,4-difluorophenyl)cyclopentyl]-N-methyl-carbamate

: 76-05-1
trifluoroacetic acid

: 1352244-97-3
[4-[2-[4-chloro-3-methyl-phenyl]-5-methyl-1,2,4-triazol-3-yl]-1-piperidyl]-[(1R,2R)-2-(2,4-difluorophenyl)-4-methylamino-cyclopentyl]methanone trifluoroacetate

Guidance literature:: In dichloromethane; at 20 ℃; for 6h;

Reference yield:

: 934989-24-9
benzyl (1R,2R,4S)-4-(tert-butoxycarbonyl(methyl)amino)-2-(2,4-difluorophenyl)-cyclopentanecarboxylate

: 1352244-97-3
[4-[2-[4-chloro-3-methyl-phenyl]-5-methyl-1,2,4-triazol-3-yl]-1-piperidyl]-[(1R,2R)-2-(2,4-difluorophenyl)-4-methylamino-cyclopentyl]methanone trifluoroacetate

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogen / 5%-palladium/activated carbon / tetrahydrofuran / 24 h / 20 °C / 760.05 Torr

2: triethylamine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / N,N-dimethyl-formamide / 16 h / 20 °C

3: dichloromethane / 6 h / 20 °C

With hydrogen; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; 5%-palladium/activated carbon; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 84358-13-4,174286-31-8
N-[(tert-butoxy)carbonyl]piperidine-4-carboxylic acid

: 1352244-97-3
[4-[2-[4-chloro-3-methyl-phenyl]-5-methyl-1,2,4-triazol-3-yl]-1-piperidyl]-[(1R,2R)-2-(2,4-difluorophenyl)-4-methylamino-cyclopentyl]methanone trifluoroacetate

Guidance literature:: Multi-step reaction with 5 steps

1.1: HATU / dichloromethane / 0.5 h / 20 °C

1.2: 16 h / 20 °C

2.1: sodium acetate; acetic acid / 1,4-dioxane / 16 h / 90 °C

3.1: dichloromethane / 16 h / 20 °C

4.1: triethylamine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / N,N-dimethyl-formamide / 16 h / 20 °C

5.1: dichloromethane / 6 h / 20 °C

With sodium acetate; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; acetic acid; triethylamine; HATU; In 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide;