tert-butyl N-[(1S,3R,4R)-3-[4-[2-(4-chloro-3-methyl-phenyl)-5-methyl-1,2,4-triazol-3-yl]piperidine-carbonyl]-4-(2,4-difluorophenyl)cyclopentyl]-N-methyl-carbamate

Base Information

Chemical Name:tert-butyl N-[(1S,3R,4R)-3-[4-[2-(4-chloro-3-methyl-phenyl)-5-methyl-1,2,4-triazol-3-yl]piperidine-carbonyl]-4-(2,4-difluorophenyl)cyclopentyl]-N-methyl-carbamate
CAS No.:1352246-48-0
Molecular Formula:C₃₃H₄₀ClF₂N₅O₃
Molecular Weight:628.162
Hs Code.:

tert-butyl N-[(1S,3R,4R)-3-[4-[2-(4-chloro-3-methyl-phenyl)-5-methyl-1,2,4-triazol-3-yl]piperidine-carbonyl]-4-(2,4-difluorophenyl)cyclopentyl]-N-methyl-carbamate

Synonyms:tert-butyl N-[(1S,3R,4R)-3-[4-[2-(4-chloro-3-methyl-phenyl)-5-methyl-1,2,4-triazol-3-yl]piperidine-carbonyl]-4-(2,4-difluorophenyl)cyclopentyl]-N-methyl-carbamate

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Chemical Property of tert-butyl N-[(1S,3R,4R)-3-[4-[2-(4-chloro-3-methyl-phenyl)-5-methyl-1,2,4-triazol-3-yl]piperidine-carbonyl]-4-(2,4-difluorophenyl)cyclopentyl]-N-methyl-carbamate

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Technology Process of tert-butyl N-[(1S,3R,4R)-3-[4-[2-(4-chloro-3-methyl-phenyl)-5-methyl-1,2,4-triazol-3-yl]piperidine-carbonyl]-4-(2,4-difluorophenyl)cyclopentyl]-N-methyl-carbamate

There total 5 articles about tert-butyl N-[(1S,3R,4R)-3-[4-[2-(4-chloro-3-methyl-phenyl)-5-methyl-1,2,4-triazol-3-yl]piperidine-carbonyl]-4-(2,4-difluorophenyl)cyclopentyl]-N-methyl-carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1352246-47-9
(1R,2R,4S)-4-(tert-butoxycarbonyl(methyl)amino)-2-(2,4-difluorophenyl)cyclopentane-carboxylic acid

: 1352246-27-5
4-[1-(4-chloro-3-methylphenyl)-3-methyl-1H-1,2,4-triazol-5-yl]piperidine trifluoroacetate

: 1352246-48-0
tert-butyl N-[(1S,3R,4R)-3-[4-[2-(4-chloro-3-methyl-phenyl)-5-methyl-1,2,4-triazol-3-yl]piperidine-carbonyl]-4-(2,4-difluorophenyl)cyclopentyl]-N-methyl-carbamate

Guidance literature:: With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 16h;

Reference yield:

: 934989-24-9
benzyl (1R,2R,4S)-4-(tert-butoxycarbonyl(methyl)amino)-2-(2,4-difluorophenyl)-cyclopentanecarboxylate

: 1352246-48-0
tert-butyl N-[(1S,3R,4R)-3-[4-[2-(4-chloro-3-methyl-phenyl)-5-methyl-1,2,4-triazol-3-yl]piperidine-carbonyl]-4-(2,4-difluorophenyl)cyclopentyl]-N-methyl-carbamate

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogen / 5%-palladium/activated carbon / tetrahydrofuran / 24 h / 20 °C / 760.05 Torr

2: triethylamine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / N,N-dimethyl-formamide / 16 h / 20 °C

With hydrogen; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; 5%-palladium/activated carbon; In tetrahydrofuran; N,N-dimethyl-formamide;

Reference yield:

: 84358-13-4,174286-31-8
N-[(tert-butoxy)carbonyl]piperidine-4-carboxylic acid

: 1352246-48-0
tert-butyl N-[(1S,3R,4R)-3-[4-[2-(4-chloro-3-methyl-phenyl)-5-methyl-1,2,4-triazol-3-yl]piperidine-carbonyl]-4-(2,4-difluorophenyl)cyclopentyl]-N-methyl-carbamate

Guidance literature:: Multi-step reaction with 4 steps

1.1: HATU / dichloromethane / 0.5 h / 20 °C

1.2: 16 h / 20 °C

2.1: sodium acetate; acetic acid / 1,4-dioxane / 16 h / 90 °C

3.1: dichloromethane / 16 h / 20 °C

4.1: triethylamine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / N,N-dimethyl-formamide / 16 h / 20 °C

With sodium acetate; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; acetic acid; triethylamine; HATU; In 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide;