N-diaminomethylene-2-methyl-4-(4-BOC-aminopiperidino)-5-methylsulphonylbenzamide

Base Information

Chemical Name:N-diaminomethylene-2-methyl-4-(4-BOC-aminopiperidino)-5-methylsulphonylbenzamide
CAS No.:168768-17-0
Molecular Formula:C₂₀H₃₁N₅O₅S
Molecular Weight:453.563
Hs Code.:

Synonyms:N-diaminomethylene-2-methyl-4-(4-BOC-aminopiperidino)-5-methylsulphonylbenzamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-diaminomethylene-2-methyl-4-(4-BOC-aminopiperidino)-5-methylsulphonylbenzamide

Chemical Property:

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Technology Process of N-diaminomethylene-2-methyl-4-(4-BOC-aminopiperidino)-5-methylsulphonylbenzamide

There total 7 articles about N-diaminomethylene-2-methyl-4-(4-BOC-aminopiperidino)-5-methylsulphonylbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 38.0%

: 113-00-8
guanidine nitrate

: 190368-03-7
4-(4-tert-Butoxycarbonylamino-piperidin-1-yl)-5-methanesulfonyl-2-methyl-benzoic acid methyl ester

: 168768-17-0
N-diaminomethylene-2-methyl-4-(4-BOC-aminopiperidino)-5-methylsulphonylbenzamide

Guidance literature:: In methanol; at 50 ℃; for 3h;
DOI:10.1021/jm960768n

Reference yield:

: 68837-59-2
4-bromo-2-methylbenzoic acid

: 168768-17-0
N-diaminomethylene-2-methyl-4-(4-BOC-aminopiperidino)-5-methylsulphonylbenzamide

Guidance literature:: Multi-step reaction with 6 steps

1: ClSO₃H / 3 h / 140 °C

2: aq. Na₂SO₃, aq. NaOH / 15 - 20 °C

3: aq. NaOH / methanol / 30 h / Heating

4: 2 h / 160 °C

5: K₂CO₃ / dimethylformamide

6: 38 percent / methanol / 3 h / 50 °C

With chlorosulfonic acid; sodium hydroxide; potassium carbonate; sodium sulfite; In methanol; N,N-dimethyl-formamide;
DOI:10.1021/jm960768n

Reference yield:

: 213120-96-8
2-bromo-4-methyl-5-carboxybenzenesulfinic acid

: 168768-17-0
N-diaminomethylene-2-methyl-4-(4-BOC-aminopiperidino)-5-methylsulphonylbenzamide

Guidance literature:: Multi-step reaction with 4 steps

1: aq. NaOH / methanol / 30 h / Heating

2: 2 h / 160 °C

3: K₂CO₃ / dimethylformamide

4: 38 percent / methanol / 3 h / 50 °C

With sodium hydroxide; potassium carbonate; In methanol; N,N-dimethyl-formamide;
DOI:10.1021/jm960768n