12-p-fluorophenylethynyl-N-methyl-5,6,7,12-tetrahydrodibenz[c,f][1,5]azastibocine

Base Information

Chemical Name:12-p-fluorophenylethynyl-N-methyl-5,6,7,12-tetrahydrodibenz[c,f][1,5]azastibocine
CAS No.:904689-19-6
Molecular Formula:C₂₃H₁₉FNSb
Molecular Weight:450.159
Hs Code.:

Synonyms:12-p-fluorophenylethynyl-N-methyl-5,6,7,12-tetrahydrodibenz[c,f][1,5]azastibocine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 12-p-fluorophenylethynyl-N-methyl-5,6,7,12-tetrahydrodibenz[c,f][1,5]azastibocine

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Technology Process of 12-p-fluorophenylethynyl-N-methyl-5,6,7,12-tetrahydrodibenz[c,f][1,5]azastibocine

There total 2 articles about 12-p-fluorophenylethynyl-N-methyl-5,6,7,12-tetrahydrodibenz[c,f][1,5]azastibocine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 766-98-3
1-ethynyl-4-fluorobenzene

: 904689-17-4
12-bromo-N-methyl-5,6,7,12-tetrahydrodibenz[c,f][1,5]azastibocine

: 904689-19-6
12-p-fluorophenylethynyl-N-methyl-5,6,7,12-tetrahydrodibenz[c,f][1,5]azastibocine

Guidance literature:: With n-BuLi; In tetrahydrofuran; diethyl ether; hexane; under Ar; n-BuLi in hexane added at 0°C to stirred soln. of FC6H4CCH in Et2O; stirred for 1 h; THF soln. of Sb compd. added dropwise at 0°C; stirred for 4 h; diluted with ether; quenched with H2O; ether layer sepd.; washed with brine; dried (anhyd. MgSO4); concd. in vac.; recrystd. from hexane-benzene; elem. anal.;
DOI:10.1016/j.jorganchem.2006.02.041

Reference yield:

: 7375-70-4
N⁽¹⁾,N⁽²⁾-bis(2-bromobenzyl)-N⁽¹⁾,N⁽²⁾-dimethylpropane-1,3-diamine

: 904689-19-6
12-p-fluorophenylethynyl-N-methyl-5,6,7,12-tetrahydrodibenz[c,f][1,5]azastibocine

Guidance literature:: Multi-step reaction with 2 steps

1: n-BuLi / diethyl ether; hexane

2: n-BuLi / diethyl ether; hexane; tetrahydrofuran

With n-BuLi; In tetrahydrofuran; diethyl ether; hexane;
DOI:10.1016/j.jorganchem.2006.02.041

Reference yield: 84.0%

: 904689-19-6
12-p-fluorophenylethynyl-N-methyl-5,6,7,12-tetrahydrodibenz[c,f][1,5]azastibocine

: 98-88-4
benzoyl chloride

: 39833-45-9
3-(4-fluorophenyl)-1-phenylprop-2-yn-1-one

Guidance literature:: With bis-triphenylphosphine-palladium(II) chloride; In 1,2-dichloro-ethane; at 20 ℃; for 1h;
DOI:10.1016/j.jorganchem.2006.02.041