6-benzoyl-5-ethyl-1-((4-fluorobenzyloxy)methyl)-3-hydroxypyrimidine-2,4(1H,3H)-dione

Base Information

Chemical Name:6-benzoyl-5-ethyl-1-((4-fluorobenzyloxy)methyl)-3-hydroxypyrimidine-2,4(1H,3H)-dione
CAS No.:1304033-84-8
Molecular Formula:C₂₁H₁₉FN₂O₅
Molecular Weight:398.391
Hs Code.:

Synonyms:6-benzoyl-5-ethyl-1-((4-fluorobenzyloxy)methyl)-3-hydroxypyrimidine-2,4(1H,3H)-dione

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Chemical Property of 6-benzoyl-5-ethyl-1-((4-fluorobenzyloxy)methyl)-3-hydroxypyrimidine-2,4(1H,3H)-dione

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Technology Process of 6-benzoyl-5-ethyl-1-((4-fluorobenzyloxy)methyl)-3-hydroxypyrimidine-2,4(1H,3H)-dione

There total 7 articles about 6-benzoyl-5-ethyl-1-((4-fluorobenzyloxy)methyl)-3-hydroxypyrimidine-2,4(1H,3H)-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

: 1304033-78-0
6-benzoyl-5-ethyl-1-((4-fluorobenzyloxy)methyl)pyrimidine-2,4(1H,3H)-dione

: 1304033-84-8
6-benzoyl-5-ethyl-1-((4-fluorobenzyloxy)methyl)-3-hydroxypyrimidine-2,4(1H,3H)-dione

Guidance literature:: 6-benzoyl-5-ethyl-1-((4-fluorobenzyloxy)methyl)pyrimidine-2,4(1H,3H)-dione; With sodium hydride; In tetrahydrofuran; at 0 - 20 ℃; Inert atmosphere;

With 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; at 0 - 20 ℃; Inert atmosphere;
DOI:10.1016/j.bmcl.2011.02.069

Reference yield:

: 459-56-3
4-fluorobenzylic alcohol

: 1304033-84-8
6-benzoyl-5-ethyl-1-((4-fluorobenzyloxy)methyl)-3-hydroxypyrimidine-2,4(1H,3H)-dione

Guidance literature:: Multi-step reaction with 3 steps

1.1: chloro-trimethyl-silane / 0.75 h / 20 °C / Inert atmosphere

2.1: N,O-bis-(trimethylsilyl)-acetamide / dichloromethane / 20 °C / Inert atmosphere

2.2: 20 °C / Inert atmosphere

3.1: sodium hydride / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

3.2: 0 - 20 °C / Inert atmosphere

With chloro-trimethyl-silane; N,O-bis-(trimethylsilyl)-acetamide; sodium hydride; In tetrahydrofuran; dichloromethane;
DOI:10.1016/j.bmcl.2011.02.069

Reference yield:

: 1780-38-7
2,4,6-trichloro-5-ethylpyrimidine

: 1304033-84-8
6-benzoyl-5-ethyl-1-((4-fluorobenzyloxy)methyl)-3-hydroxypyrimidine-2,4(1H,3H)-dione

Guidance literature:: Multi-step reaction with 5 steps

1.1: methanol / Inert atmosphere

2.1: sodium hydride / N,N-dimethyl-formamide / 20 °C / Inert atmosphere

2.2: air / Inert atmosphere

3.1: hydrogenchloride; water / methanol / Inert atmosphere; Reflux

4.1: N,O-bis-(trimethylsilyl)-acetamide / dichloromethane / 20 °C / Inert atmosphere

4.2: 20 °C / Inert atmosphere

5.1: sodium hydride / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

5.2: 0 - 20 °C / Inert atmosphere

With hydrogenchloride; N,O-bis-(trimethylsilyl)-acetamide; water; sodium hydride; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2011.02.069