5-[5-amino-1-(1,1-dimethylethyl)-3-methyl-1H-pyrazol-4-yl]-3-fluoro-2-(methyloxy)phenol

Base Information

Chemical Name:5-[5-amino-1-(1,1-dimethylethyl)-3-methyl-1H-pyrazol-4-yl]-3-fluoro-2-(methyloxy)phenol
CAS No.:838856-94-3
Molecular Formula:C₁₅H₂₀FN₃O₂
Molecular Weight:293.341
Hs Code.:

Synonyms:5-[5-amino-1-(1,1-dimethylethyl)-3-methyl-1H-pyrazol-4-yl]-3-fluoro-2-(methyloxy)phenol

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Chemical Property of 5-[5-amino-1-(1,1-dimethylethyl)-3-methyl-1H-pyrazol-4-yl]-3-fluoro-2-(methyloxy)phenol

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Technology Process of 5-[5-amino-1-(1,1-dimethylethyl)-3-methyl-1H-pyrazol-4-yl]-3-fluoro-2-(methyloxy)phenol

There total 13 articles about 5-[5-amino-1-(1,1-dimethylethyl)-3-methyl-1H-pyrazol-4-yl]-3-fluoro-2-(methyloxy)phenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₂H₂₆FN₃O₂*ClH

: 838856-94-3
5-[5-amino-1-(1,1-dimethylethyl)-3-methyl-1H-pyrazol-4-yl]-3-fluoro-2-(methyloxy)phenol

Guidance literature:: C₂₂H₂₆FN₃O₂*ClH; With hydrogen; palladium 10% on activated carbon; In ethanol; at 20 ℃; for 9h; under 2585.81 Torr;

With sodium hydrogencarbonate; In water; ethyl acetate; pH=7;

Reference yield:

: 838856-91-0
5-(chloromethyl)-1-fluoro-2-(methyloxy)-3-[(phenylmethyl)oxy]benzene

: 838856-94-3
5-[5-amino-1-(1,1-dimethylethyl)-3-methyl-1H-pyrazol-4-yl]-3-fluoro-2-(methyloxy)phenol

Guidance literature:: Multi-step reaction with 4 steps

1.1: N,N-dimethyl-formamide / 12 h / 20 °C

2.1: sodium hydride / tetrahydrofuran / 0.58 h / 0 - 20 °C

3.1: ethanol / 12 h / 75 °C

4.1: hydrogen / palladium 10% on activated carbon / ethanol / 9 h / 20 °C / 2585.81 Torr

4.2: pH 7

With hydrogen; sodium hydride; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide;

Reference yield:

: 838856-88-5
3-fluoro-5-hydroxy-4-methoxybenzoic acid methyl ester

: 838856-94-3
5-[5-amino-1-(1,1-dimethylethyl)-3-methyl-1H-pyrazol-4-yl]-3-fluoro-2-(methyloxy)phenol

Guidance literature:: Multi-step reaction with 7 steps

1.1: caesium carbonate / N,N-dimethyl-formamide / 12 h / 20 °C

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 0.5 h / 0 °C

3.1: pyridine; thionyl chloride / dichloromethane / 0.08 h / 0 - 20 °C

4.1: N,N-dimethyl-formamide / 12 h / 20 °C

5.1: sodium hydride / tetrahydrofuran / 0.58 h / 0 - 20 °C

6.1: ethanol / 12 h / 75 °C

7.1: hydrogen / palladium 10% on activated carbon / ethanol / 9 h / 20 °C / 2585.81 Torr

7.2: pH 7

With pyridine; lithium aluminium tetrahydride; thionyl chloride; hydrogen; sodium hydride; caesium carbonate; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide;