3-(4-ferrocenoylbutanamido)-2,4-dihydroxybenzoic acid

Base Information

• Chemical Name: 3-(4-ferrocenoylbutanamido)-2,4-dihydroxybenzoic acid
• CAS No.: 1243248-55-6
• Molecular Formula: C₂₂H₂₁FeNO₆
• Molecular Weight: 451.259
• Mol file: 1243248-55-6.mol

Synonyms:3-(4-ferrocenoylbutanamido)-2,4-dihydroxybenzoic acid

Chemical Property of 3-(4-ferrocenoylbutanamido)-2,4-dihydroxybenzoic acid

Chemical Property:

Purity/Quality:

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Technology Process of 3-(4-ferrocenoylbutanamido)-2,4-dihydroxybenzoic acid

There total 3 articles about 3-(4-ferrocenoylbutanamido)-2,4-dihydroxybenzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

hydrogenchloride (7647-01-0,15364-23-5) + lithium hydroxide monohydrate (1310-66-3) + (cyclopentadienyl)FeC5H4C(O)CH2CH2CH2C(O)NHC6H2(OMOM)2(CO2Me) (1247085-60-4) → 3-(4-ferrocenoylbutanamido)-2,4-dihydroxybenzoic acid (1243248-55-6)

Guidance literature:

In tetrahydrofuran; water; Schlenk techniques; under Ar addn. of Li compd. to soln. of Fe complex in THF/H2O (4/1), heating at 45°C for 20 h, evapn. under vacuum, slow addn. of 4 N HCl in dioxane to pH near 0, stirring at room temp. for20 min; addn. of brine, extn. (EtOAc), washing with water and brine, drying (Na2SO4), filtration, concn., flash chromy. (silica gel, EtOAc/MeOH/AcOH from 1:0:0 to 20:1:0.1), concn., addn. of pentane, isolation of solid, elem. anal.;

DOI:10.1021/om100614c

Reference yield:

((cyclopentadienyl)FeC5H4C(O))2CHCH2CH2C(O)NHC6H2(OH)2COOMe (1247085-41-1) + water (7732-18-5) + sodium hydroxide (1310-73-2) → ferrocenecarboxylic acid (1271-42-7) + 3-(4-ferrocenoylbutanamido)-2,4-dihydroxybenzoic acid (1243248-55-6)

Guidance literature:

In tetrahydrofuran; methanol; water; Schlenk techniques; addn. of aq. NaOH to soln. of Fe complex in THF/MeOH;

DOI:10.1021/om100614c

Reference yield:

hydrogenchloride (7647-01-0,15364-23-5) + (cyclopentadienyl)FeC5H4C(O)CH2CH2CH2C(O)NHC6H2(OMOM)2(CO2Me) (1247085-60-4) + lithium hydroxide (1310-65-2) → 3-(4-ferrocenoylbutanamido)-2,4-dihydroxybenzoic acid (1243248-55-6)

Guidance literature:

In tetrahydrofuran; water; Schlenk techniques; under Ar addn. of Li compd. to soln. of Fe complex in THF/H2O (4/1), heating at 45°C for 20 h, evapn. under vacuum, slow addn. of 4 N HCl in dioxane to pH near 0, stirring at room temp. for20 min;

DOI:10.1021/om100614c

upstream raw materials:

((cyclopentadienyl)FeC₅H₄C(O))2CHCH₂CH₂C(O)NHC₆H₂(OH)2COOMe

water

sodium hydroxide

hydrogenchloride

Refernces