{(S)-1-[(2S,5R)-2-Isopropyl-5-methyl-cyclohex-(E)-ylidenemethyl]-2,2-dimethyl-propyl}-carbamic acid methyl ester

Base Information

Chemical Name:{(S)-1-[(2S,5R)-2-Isopropyl-5-methyl-cyclohex-(E)-ylidenemethyl]-2,2-dimethyl-propyl}-carbamic acid methyl ester
CAS No.:750594-60-6
Molecular Formula:C₁₈H₃₃NO₂
Molecular Weight:295.466
Hs Code.:

Synonyms:{(S)-1-[(2S,5R)-2-Isopropyl-5-methyl-cyclohex-(E)-ylidenemethyl]-2,2-dimethyl-propyl}-carbamic acid methyl ester

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Chemical Property of {(S)-1-[(2S,5R)-2-Isopropyl-5-methyl-cyclohex-(E)-ylidenemethyl]-2,2-dimethyl-propyl}-carbamic acid methyl ester

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Technology Process of {(S)-1-[(2S,5R)-2-Isopropyl-5-methyl-cyclohex-(E)-ylidenemethyl]-2,2-dimethyl-propyl}-carbamic acid methyl ester

There total 4 articles about {(S)-1-[(2S,5R)-2-Isopropyl-5-methyl-cyclohex-(E)-ylidenemethyl]-2,2-dimethyl-propyl}-carbamic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 124-41-4
sodium methylate

: 750594-59-3
(S)-2-[(2S,5R)-2-Isopropyl-5-methyl-cyclohex-(E)-ylidenemethyl]-3,3-dimethyl-butyric acid

: 750594-60-6
{(S)-1-[(2S,5R)-2-Isopropyl-5-methyl-cyclohex-(E)-ylidenemethyl]-2,2-dimethyl-propyl}-carbamic acid methyl ester

Guidance literature:: (S)-2-[(2S,5R)-2-Isopropyl-5-methyl-cyclohex-(E)-ylidenemethyl]-3,3-dimethyl-butyric acid; With diphenyl-phosphinic acid; triethylamine; In toluene; for 1h; Heating;

sodium methylate; In methanol; for 1h; Heating;
DOI:10.1021/ol048936q

Reference yield:

: 750594-48-0
(1R,2S,5R)-2-i-propyl-5-methyl-1-(3-t-butyldimethylsyloxy-1-propen-1-yl)cyclohexan-1-ol

: 750594-60-6
{(S)-1-[(2S,5R)-2-Isopropyl-5-methyl-cyclohex-(E)-ylidenemethyl]-2,2-dimethyl-propyl}-carbamic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: n-BuLi / tetrahydrofuran; hexane / 1 h / -78 - 0 °C

1.2: tetrahydrofuran; hexane / 2 h / 0 - 20 °C

2.1: CuCN / tetrahydrofuran; pentane / 0.5 h / -78 °C

2.2: 1.09 g / tetrahydrofuran; pentane / 4 h / -78 - 20 °C

3.1: 100 percent / Jones reagent / acetone / 2 h / 0 °C

4.1: DPPA; Et₃N / toluene / 1 h / Heating

4.2: 76 percent / methanol / 1 h / Heating

With n-butyllithium; jones reagent; diphenyl-phosphinic acid; triethylamine; In tetrahydrofuran; hexane; acetone; toluene; pentane; 4.1: Curtius rearrangement;
DOI:10.1021/ol048936q

Reference yield:

: 750594-50-4
Carbonic acid (1R,2S,5R)-1-[(E)-3-(tert-butyl-dimethyl-silanyloxy)-propenyl]-2-isopropyl-5-methyl-cyclohexyl ester methyl ester

: 750594-60-6
{(S)-1-[(2S,5R)-2-Isopropyl-5-methyl-cyclohex-(E)-ylidenemethyl]-2,2-dimethyl-propyl}-carbamic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: CuCN / tetrahydrofuran; pentane / 0.5 h / -78 °C

1.2: 1.09 g / tetrahydrofuran; pentane / 4 h / -78 - 20 °C

2.1: 100 percent / Jones reagent / acetone / 2 h / 0 °C

3.1: DPPA; Et₃N / toluene / 1 h / Heating

3.2: 76 percent / methanol / 1 h / Heating

With jones reagent; diphenyl-phosphinic acid; triethylamine; In tetrahydrofuran; acetone; toluene; pentane; 3.1: Curtius rearrangement;
DOI:10.1021/ol048936q