trimethyl 4-oxo-3-(phenylseleno)cyclohexane-1,1,3-tricarboxylate

Base Information

• Chemical Name: trimethyl 4-oxo-3-(phenylseleno)cyclohexane-1,1,3-tricarboxylate
• CAS No.: 159124-48-8
• Molecular Formula: C₁₈H₂₀O₇Se
• Molecular Weight: 427.313
• Mol file: 159124-48-8.mol

Synonyms:trimethyl 4-oxo-3-(phenylseleno)cyclohexane-1,1,3-tricarboxylate

Chemical Property of trimethyl 4-oxo-3-(phenylseleno)cyclohexane-1,1,3-tricarboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of trimethyl 4-oxo-3-(phenylseleno)cyclohexane-1,1,3-tricarboxylate

There total 2 articles about trimethyl 4-oxo-3-(phenylseleno)cyclohexane-1,1,3-tricarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

malonic acid dimethyl ester (108-59-8) → trimethyl 4-oxo-3-(phenylseleno)cyclohexane-1,1,3-tricarboxylate (159124-48-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 100 percent / NaH

2: 1.) pyridine / 1.) CH₂Cl₂

With pyridine; sodium hydride;

DOI:10.1021/jo00101a033

Reference yield:

Phenylselenyl chloride (5707-04-0) + trimethyl 4-oxocyclohexane-1,1,3-tricarboxylate (80269-67-6) → trimethyl 4-oxo-3-(phenylseleno)cyclohexane-1,1,3-tricarboxylate (159124-48-8)

Guidance literature:

With pyridine; Yield given. Multistep reaction; 1.) CH₂Cl₂;

DOI:10.1021/jo00101a033

Reference yield: 100.0%

trimethyl 4-oxo-3-(phenylseleno)cyclohexane-1,1,3-tricarboxylate (159124-48-8) → trimethyl 4-oxo-2-cyclohexene-1,1,3-tricarboxylate (159124-50-2)

Guidance literature:

With dihydrogen peroxide; In dichloromethane; at 0 ℃; for 0.666667h;

DOI:10.1021/jo00101a033

upstream raw materials:

Phenylselenyl chloride

trimethyl 4-oxocyclohexane-1,1,3-tricarboxylate

malonic acid dimethyl ester

Downstream raw materials:

trimethyl 4-oxo-2-cyclohexene-1,1,3-tricarboxylate