2-[3-cyclopropyl-4-(cyclopropylsulfonyl)phenyl]-3-[(2R,3R,7R)-2,3-diphenyl-1,4-dioxaspiro[4.4]non-7-yl]propionic acid

Base Information

• Chemical Name: 2-[3-cyclopropyl-4-(cyclopropylsulfonyl)phenyl]-3-[(2R,3R,7R)-2,3-diphenyl-1,4-dioxaspiro[4.4]non-7-yl]propionic acid
• CAS No.: 1174231-38-9
• Molecular Formula: C₃₄H₃₆O₆S
• Molecular Weight: 572.722
• Mol file: 1174231-38-9.mol

Synonyms:2-[3-cyclopropyl-4-(cyclopropylsulfonyl)phenyl]-3-[(2R,3R,7R)-2,3-diphenyl-1,4-dioxaspiro[4.4]non-7-yl]propionic acid

Chemical Property of 2-[3-cyclopropyl-4-(cyclopropylsulfonyl)phenyl]-3-[(2R,3R,7R)-2,3-diphenyl-1,4-dioxaspiro[4.4]non-7-yl]propionic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-[3-cyclopropyl-4-(cyclopropylsulfonyl)phenyl]-3-[(2R,3R,7R)-2,3-diphenyl-1,4-dioxaspiro[4.4]non-7-yl]propionic acid

There total 1 articles about 2-[3-cyclopropyl-4-(cyclopropylsulfonyl)phenyl]-3-[(2R,3R,7R)-2,3-diphenyl-1,4-dioxaspiro[4.4]non-7-yl]propionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methyl 2-[3-cyclopropyl-4-(cyclopropylsulfonyl)phenyl]-3-[(2R,3R,7R)-2,3-diphenyl-1,4-dioxaspiro[4.4]non-7-yl]propionate (1174229-46-9) → 2-[3-cyclopropyl-4-(cyclopropylsulfonyl)phenyl]-3-[(2R,3R,7R)-2,3-diphenyl-1,4-dioxaspiro[4.4]non-7-yl]propionic acid (1174231-38-9)

Guidance literature:

methyl 2-[3-cyclopropyl-4-(cyclopropylsulfonyl)phenyl]-3-[(2R,3R,7R)-2,3-diphenyl-1,4-dioxaspiro[4.4]non-7-yl]propionate; With water; sodium hydroxide; In tetrahydrofuran; methanol; for 0.5h; Reflux;

With hydrogenchloride; In chloroform; water; Cooling with ice;

Reference yield:

2-[3-cyclopropyl-4-(cyclopropylsulfonyl)phenyl]-3-[(2R,3R,7R)-2,3-diphenyl-1,4-dioxaspiro[4.4]non-7-yl]propionic acid (1174231-38-9) + pivaloyl chloride (3282-30-2) → C39H44O7S

Guidance literature:

With triethylamine; In tetrahydrofuran; at 11 - 20 ℃;

Reference yield:

2-[3-cyclopropyl-4-(cyclopropylsulfonyl)phenyl]-3-[(2R,3R,7R)-2,3-diphenyl-1,4-dioxaspiro[4.4]non-7-yl]propionic acid (1174231-38-9) → (2R)-2-(4-cyclopropanesulfonyl-3-cyclopropylphenyl)-3-[(2R,3R,7R)-2,3-diphenyl-1,4-dioxaspiro[4.4]nonan-7-yl]propanoic acid + (2S)-2-(4-cyclopropanesulfonyl-3-cyclopropylphenyl)-3-[(2R,3R,7R)-2,3-diphenyl-1,4-dioxaspiro[4.4]nonan-7-yl]propanoic acid

Guidance literature:

With 1-methyl-1H-imidazole; p-toluenesulfonyl chloride; In acetonitrile; at 25 ℃; for 2h; Solvent; Reagent/catalyst; Temperature; Inert atmosphere;

DOI:10.1021/acs.oprd.6b00415

upstream raw materials:

methyl 2-[3-cyclopropyl-4-(cyclopropylsulfonyl)phenyl]-3-[(2R,3R,7R)-2,3-diphenyl-1,4-dioxaspiro[4.4]non-7-yl]propionate

Downstream raw materials:

(2R)-2-(4-cyclopropanesulfonyl-3-cyclopropylphenyl)-3-[(R)-3-oxocyclopentyl]propanoic acid

(2R)-2-(4-cyclopropanesulfonyl-3-cyclopropylphenyl)-N-[5-(hydroxymethyl)pyrazin-2-yl]-3-[(R)-3-oxocyclopentyl]propanamide

C₃₁H₄₃N₃O₅SSi