2,2-Dimethyl-propionic acid (R)-3-((S)-3-oxo-1-phenyl-butoxy)-5-((2R,4S)-2-phenyl-[1,3]dioxan-4-yl)-pentyl ester

Base Information

Chemical Name:2,2-Dimethyl-propionic acid (R)-3-((S)-3-oxo-1-phenyl-butoxy)-5-((2R,4S)-2-phenyl-[1,3]dioxan-4-yl)-pentyl ester
CAS No.:474333-83-0
Molecular Formula:C₃₀H₄₀O₆
Molecular Weight:496.644
Hs Code.:

Synonyms:2,2-Dimethyl-propionic acid (R)-3-((S)-3-oxo-1-phenyl-butoxy)-5-((2R,4S)-2-phenyl-[1,3]dioxan-4-yl)-pentyl ester

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Chemical Property of 2,2-Dimethyl-propionic acid (R)-3-((S)-3-oxo-1-phenyl-butoxy)-5-((2R,4S)-2-phenyl-[1,3]dioxan-4-yl)-pentyl ester

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Technology Process of 2,2-Dimethyl-propionic acid (R)-3-((S)-3-oxo-1-phenyl-butoxy)-5-((2R,4S)-2-phenyl-[1,3]dioxan-4-yl)-pentyl ester

There total 3 articles about 2,2-Dimethyl-propionic acid (R)-3-((S)-3-oxo-1-phenyl-butoxy)-5-((2R,4S)-2-phenyl-[1,3]dioxan-4-yl)-pentyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 2,2-Dimethyl-propionic acid (R)-3-((S)-3-methyl-1-phenyl-but-3-enyloxy)-5-((2R,4R)-2-phenyl-[1,3]dioxan-4-yl)-pentyl ester

: 474333-83-0
2,2-Dimethyl-propionic acid (R)-3-((S)-3-oxo-1-phenyl-butoxy)-5-((2R,4S)-2-phenyl-[1,3]dioxan-4-yl)-pentyl ester

Guidance literature:: 2,2-Dimethyl-propionic acid (R)-3-((S)-3-methyl-1-phenyl-but-3-enyloxy)-5-((2R,4R)-2-phenyl-[1,3]dioxan-4-yl)-pentyl ester; With osmium(VIII) oxide; 4-methylmorpholine N-oxide; In water; acetone; tert-butyl alcohol; for 12h;

With sodium periodate; In water; acetone; tert-butyl alcohol; for 1h; Further stages.;
DOI:10.1021/jo025944g

Reference yield:

: 474333-79-4
(R)-3-((S)-3-Methyl-1-phenyl-but-3-enyloxy)-5-((2R,4S)-2-phenyl-[1,3]dioxan-4-yl)-pentan-1-ol

: 474333-83-0
2,2-Dimethyl-propionic acid (R)-3-((S)-3-oxo-1-phenyl-butoxy)-5-((2R,4S)-2-phenyl-[1,3]dioxan-4-yl)-pentyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: 70 percent / pyridine; 4-(N,N-dimethylamino)pyridine / CH₂Cl₂ / 11 h / 20 °C

2.1: N-methylmorpholine oxide; OsO₄ / acetone; H₂O; 2-methyl-propan-2-ol / 12 h

2.2: 95 percent / NaIO₄ / acetone; H₂O; 2-methyl-propan-2-ol / 1 h

With pyridine; dmap; osmium(VIII) oxide; 4-methylmorpholine N-oxide; In dichloromethane; water; acetone; tert-butyl alcohol;
DOI:10.1021/jo025944g

Reference yield:

: 3282-30-2
pivaloyl chloride

: 474333-83-0
2,2-Dimethyl-propionic acid (R)-3-((S)-3-oxo-1-phenyl-butoxy)-5-((2R,4S)-2-phenyl-[1,3]dioxan-4-yl)-pentyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: 70 percent / pyridine; 4-(N,N-dimethylamino)pyridine / CH₂Cl₂ / 11 h / 20 °C

2.1: N-methylmorpholine oxide; OsO₄ / acetone; H₂O; 2-methyl-propan-2-ol / 12 h

2.2: 95 percent / NaIO₄ / acetone; H₂O; 2-methyl-propan-2-ol / 1 h

With pyridine; dmap; osmium(VIII) oxide; 4-methylmorpholine N-oxide; In dichloromethane; water; acetone; tert-butyl alcohol;
DOI:10.1021/jo025944g