((5aS,6S,6aR)-3-phenyl-5,5a,6,6a,7,8-hexahydro-4H-cyclopropa[5,6]cycloocta[1,2-d]isoxazol-6-yl)methanol

Base Information

Chemical Name:((5aS,6S,6aR)-3-phenyl-5,5a,6,6a,7,8-hexahydro-4H-cyclopropa[5,6]cycloocta[1,2-d]isoxazol-6-yl)methanol
CAS No.:1285573-31-0
Molecular Formula:C₁₇H₁₉NO₂
Molecular Weight:269.343
Hs Code.:

Synonyms:((5aS,6S,6aR)-3-phenyl-5,5a,6,6a,7,8-hexahydro-4H-cyclopropa[5,6]cycloocta[1,2-d]isoxazol-6-yl)methanol

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Chemical Property of ((5aS,6S,6aR)-3-phenyl-5,5a,6,6a,7,8-hexahydro-4H-cyclopropa[5,6]cycloocta[1,2-d]isoxazol-6-yl)methanol

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Technology Process of ((5aS,6S,6aR)-3-phenyl-5,5a,6,6a,7,8-hexahydro-4H-cyclopropa[5,6]cycloocta[1,2-d]isoxazol-6-yl)methanol

There total 3 articles about ((5aS,6S,6aR)-3-phenyl-5,5a,6,6a,7,8-hexahydro-4H-cyclopropa[5,6]cycloocta[1,2-d]isoxazol-6-yl)methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 1263166-90-0
(1R,8S,9S)‐bicyclo[6.1.0]non‐4‐yn‐9‐ylmethanol

: 932-90-1
Benzaldoxime

: 1285573-31-0
((5aS,6S,6aR)-3-phenyl-5,5a,6,6a,7,8-hexahydro-4H-cyclopropa[5,6]cycloocta[1,2-d]isoxazol-6-yl)methanol

Guidance literature:: With bis-[(trifluoroacetoxy)iodo]benzene; In methanol; water; at 20 ℃; regioselective reaction;
DOI:10.1039/c0cc04646a

Reference yield:

: 100-52-7
benzaldehyde

: 1285573-31-0
((5aS,6S,6aR)-3-phenyl-5,5a,6,6a,7,8-hexahydro-4H-cyclopropa[5,6]cycloocta[1,2-d]isoxazol-6-yl)methanol

Guidance literature:: Multi-step reaction with 2 steps

1: hydroxylamine hydrochloride; sodium hydroxide / methanol; water / 0.5 h / 20 °C

2: bis-[(trifluoroacetoxy)iodo]benzene / methanol; water / 20 °C

With hydroxylamine hydrochloride; bis-[(trifluoroacetoxy)iodo]benzene; sodium hydroxide; In methanol; water;
DOI:10.1039/c0cc04646a

Reference yield:

: 1263166-90-0
(1R,8S,9S)‐bicyclo[6.1.0]non‐4‐yn‐9‐ylmethanol

: 622-79-7
benzyl azide

: 932-90-1
Benzaldoxime

: 1285573-31-0
((5aS,6S,6aR)-3-phenyl-5,5a,6,6a,7,8-hexahydro-4H-cyclopropa[5,6]cycloocta[1,2-d]isoxazol-6-yl)methanol

: C₁₇H₂₁N₃O

Guidance literature:: benzyl azide; Benzaldoxime; With bis-[(trifluoroacetoxy)iodo]benzene; In water-d2; d⁽⁴⁾-methanol; for 0.0166667h;

(1R,8S,9S)‐bicyclo[6.1.0]non‐4‐yn‐9‐ylmethanol; In water-d2; d⁽⁴⁾-methanol; for 0.166667h;
DOI:10.1039/c0cc04646a