methyl N-benzoyl-N-[piperidin-4-yl-N-(tritylimidazol-4-ylmethyl)]-(S)-methioninate

Base Information

Chemical Name:methyl N-benzoyl-N-[piperidin-4-yl-N-(tritylimidazol-4-ylmethyl)]-(S)-methioninate
CAS No.:397867-86-6
Molecular Formula:C₄₁H₄₄N₄O₃S
Molecular Weight:672.891
Hs Code.:

Synonyms:methyl N-benzoyl-N-[piperidin-4-yl-N-(tritylimidazol-4-ylmethyl)]-(S)-methioninate

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Chemical Property of methyl N-benzoyl-N-[piperidin-4-yl-N-(tritylimidazol-4-ylmethyl)]-(S)-methioninate

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Technology Process of methyl N-benzoyl-N-[piperidin-4-yl-N-(tritylimidazol-4-ylmethyl)]-(S)-methioninate

There total 5 articles about methyl N-benzoyl-N-[piperidin-4-yl-N-(tritylimidazol-4-ylmethyl)]-(S)-methioninate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 103057-10-9
4-chloromethyl-1-tritylimidazole

: methyl N-benzoyl-N-(piperidin-4-yl)-(S)-methioninate hydrochloride

: 397867-86-6
methyl N-benzoyl-N-[piperidin-4-yl-N-(tritylimidazol-4-ylmethyl)]-(S)-methioninate

Guidance literature:: With triethylamine; In acetone; at 50 ℃; for 8h;
DOI:10.1021/jm010297r

Reference yield:

: 79099-07-3
N-tert-butyloxycarbonylpiperidin-4-one

: 397867-86-6
methyl N-benzoyl-N-[piperidin-4-yl-N-(tritylimidazol-4-ylmethyl)]-(S)-methioninate

Guidance literature:: Multi-step reaction with 4 steps

1: 68 percent / molecular sieves 3 Angstroem; N(Et)3 / methanol / 4 h / 50 °C

2: 58 percent / CH₂Cl₂ / 4 h / 20 °C

3: 87 percent / HCl; MeOH / tetrahydrofuran / 16 h / 20 °C

4: 80 percent / Et₃N / acetone / 8 h / 50 °C

With hydrogenchloride; methanol; 3 A molecular sieve; triethylamine; In tetrahydrofuran; methanol; dichloromethane; acetone;
DOI:10.1021/jm010297r

Reference yield:

: 33769-07-2
4-(hydroxymethyl)-1-(triphenylmethyl)imidazole

: 397867-86-6
methyl N-benzoyl-N-[piperidin-4-yl-N-(tritylimidazol-4-ylmethyl)]-(S)-methioninate

Guidance literature:: Multi-step reaction with 2 steps

1: 81 percent / SOCl₂ / CH₂Cl₂ / 0 - 20 °C

2: 80 percent / Et₃N / acetone / 8 h / 50 °C

With thionyl chloride; triethylamine; In dichloromethane; acetone;
DOI:10.1021/jm010297r