(S)-N-(1-cyanocyclopropyl)-4,4-difluoro-5-phenyl-2-((S)-2,2,2-trifluoro-1-(4-fluorophenyl)ethylamino)pentanamide

Base Information

Chemical Name:(S)-N-(1-cyanocyclopropyl)-4,4-difluoro-5-phenyl-2-((S)-2,2,2-trifluoro-1-(4-fluorophenyl)ethylamino)pentanamide
CAS No.:1017930-77-6
Molecular Formula:C₂₃H₂₁F₆N₃O
Molecular Weight:469.43
Hs Code.:

Synonyms:(S)-N-(1-cyanocyclopropyl)-4,4-difluoro-5-phenyl-2-((S)-2,2,2-trifluoro-1-(4-fluorophenyl)ethylamino)pentanamide

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Chemical Property of (S)-N-(1-cyanocyclopropyl)-4,4-difluoro-5-phenyl-2-((S)-2,2,2-trifluoro-1-(4-fluorophenyl)ethylamino)pentanamide

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Technology Process of (S)-N-(1-cyanocyclopropyl)-4,4-difluoro-5-phenyl-2-((S)-2,2,2-trifluoro-1-(4-fluorophenyl)ethylamino)pentanamide

There total 4 articles about (S)-N-(1-cyanocyclopropyl)-4,4-difluoro-5-phenyl-2-((S)-2,2,2-trifluoro-1-(4-fluorophenyl)ethylamino)pentanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1017934-67-6
(S)-4,4-difluoro-5-phenyl-2-((S)-2,2,2-trifluoro-1-(4-fluorophenyl)ethylamino)pentanoic acid

: 127946-77-4
1-amino-1-cyclopropanecarbonitrile hydrochloride

: 1017930-77-6
(S)-N-(1-cyanocyclopropyl)-4,4-difluoro-5-phenyl-2-((S)-2,2,2-trifluoro-1-(4-fluorophenyl)ethylamino)pentanamide

Guidance literature:: With 4-methyl-morpholine; HATU; In N,N-dimethyl-formamide; at 20 ℃; for 2h;

Reference yield:

: 850646-48-9
(2S)-2-benzyloxycarbonylamino-4-oxo-5-phenylpentanoic acid methyl ester

: 1017930-77-6
(S)-N-(1-cyanocyclopropyl)-4,4-difluoro-5-phenyl-2-((S)-2,2,2-trifluoro-1-(4-fluorophenyl)ethylamino)pentanamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: diethylamino-sulfur trifluoride / 72 h / 20 °C

2.1: hydrogen bromide / 2 h / 20 °C

3.1: potassium carbonate / methanol / 50 °C

3.2: -30 - 20 °C

4.1: 4-methyl-morpholine; HATU / N,N-dimethyl-formamide / 2 h / 20 °C

With 4-methyl-morpholine; diethylamino-sulfur trifluoride; hydrogen bromide; potassium carbonate; HATU; In methanol; N,N-dimethyl-formamide;

Reference yield:

: 850646-50-3
(S)-2-benzyloxycarbonylamino-4,4-difluoro-5-phenyl-pentanoic acid methyl ester

: 1017930-77-6
(S)-N-(1-cyanocyclopropyl)-4,4-difluoro-5-phenyl-2-((S)-2,2,2-trifluoro-1-(4-fluorophenyl)ethylamino)pentanamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydrogen bromide / 2 h / 20 °C

2.1: potassium carbonate / methanol / 50 °C

2.2: -30 - 20 °C

3.1: 4-methyl-morpholine; HATU / N,N-dimethyl-formamide / 2 h / 20 °C

With 4-methyl-morpholine; hydrogen bromide; potassium carbonate; HATU; In methanol; N,N-dimethyl-formamide;