(S)-2-benzyloxycarbonylamino-4,4-difluoro-5-phenyl-pentanoic acid methyl ester

Base Information

Chemical Name:(S)-2-benzyloxycarbonylamino-4,4-difluoro-5-phenyl-pentanoic acid methyl ester
CAS No.:850646-50-3
Molecular Formula:C₂₀H₂₁F₂NO₄
Molecular Weight:377.388
Hs Code.:

Synonyms:(S)-2-benzyloxycarbonylamino-4,4-difluoro-5-phenyl-pentanoic acid methyl ester

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Chemical Property of (S)-2-benzyloxycarbonylamino-4,4-difluoro-5-phenyl-pentanoic acid methyl ester

Chemical Property:

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Technology Process of (S)-2-benzyloxycarbonylamino-4,4-difluoro-5-phenyl-pentanoic acid methyl ester

There total 4 articles about (S)-2-benzyloxycarbonylamino-4,4-difluoro-5-phenyl-pentanoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.1%

: 850646-48-9
(2S)-2-benzyloxycarbonylamino-4-oxo-5-phenylpentanoic acid methyl ester

: 850646-50-3
(S)-2-benzyloxycarbonylamino-4,4-difluoro-5-phenyl-pentanoic acid methyl ester

Guidance literature:: (2S)-2-benzyloxycarbonylamino-4-oxo-5-phenylpentanoic acid methyl ester; With diethylamino-sulfur trifluoride; at 20 ℃; for 72h;

With sodium hydroxide; In dichloromethane; water;

Reference yield:

: 958852-73-8
(S)-2-benzyloxycarbonylamino-4,4-difluoro-5-phenylpentanoic acid

: 850646-50-3
(S)-2-benzyloxycarbonylamino-4,4-difluoro-5-phenyl-pentanoic acid methyl ester

Guidance literature:: With chloro-trimethyl-silane; In methanol;

Reference yield:

: 4668-42-2
(S)-2-benzyloxycarbonylamino-succinic acid 1-methyl ester

: 850646-50-3
(S)-2-benzyloxycarbonylamino-4,4-difluoro-5-phenyl-pentanoic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: thionyl chloride / tetrahydrofuran / 1 h / 0 °C / Inert atmosphere; Reflux

2: lithium bromide; copper(I) bromide dimethylsulfide complex / tetrahydrofuran / 0.5 h / -78 °C

3: diethylamino-sulfur trifluoride / 72 h / 20 °C

With thionyl chloride; copper(I) bromide dimethylsulfide complex; diethylamino-sulfur trifluoride; lithium bromide; In tetrahydrofuran;