ethyl 1-(4-(4-fluorobenzyl)-4H-thieno[3,2-b]pyrrole-5-carbonyl)-piperidine-4-carboxylate

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Chemical Name:ethyl 1-(4-(4-fluorobenzyl)-4H-thieno[3,2-b]pyrrole-5-carbonyl)-piperidine-4-carboxylate
CAS No.:1047023-77-7
Molecular Formula:C₂₂H₂₃FN₂O₃S
Molecular Weight:414.501
Hs Code.:

Synonyms:ethyl 1-(4-(4-fluorobenzyl)-4H-thieno[3,2-b]pyrrole-5-carbonyl)-piperidine-4-carboxylate

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Chemical Property of ethyl 1-(4-(4-fluorobenzyl)-4H-thieno[3,2-b]pyrrole-5-carbonyl)-piperidine-4-carboxylate

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Technology Process of ethyl 1-(4-(4-fluorobenzyl)-4H-thieno[3,2-b]pyrrole-5-carbonyl)-piperidine-4-carboxylate

There total 7 articles about ethyl 1-(4-(4-fluorobenzyl)-4H-thieno[3,2-b]pyrrole-5-carbonyl)-piperidine-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 1126-09-6
4-carbethoxypiperidine

: 897774-27-5
C₁₄H₁₀FNO₂S

: 1047023-77-7
ethyl 1-(4-(4-fluorobenzyl)-4H-thieno[3,2-b]pyrrole-5-carbonyl)-piperidine-4-carboxylate

Guidance literature:: C₁₄H₁₀FNO₂S; With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 0.5h;

4-carbethoxypiperidine; In dichloromethane; at 20 ℃; for 16h;
DOI:10.1021/jm300214e

Reference yield:

: 82782-85-2
thieno<3,2-b>pyrrole-5-carboxylic acid methyl ester

: 1047023-77-7
ethyl 1-(4-(4-fluorobenzyl)-4H-thieno[3,2-b]pyrrole-5-carbonyl)-piperidine-4-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 18 h / 60 °C

2.1: potassium hydroxide / ethanol; water / 16 h / 40 °C

3.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / dichloromethane / 0.5 h / 20 °C

3.2: 16 h / 20 °C

With potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; potassium hydroxide; In ethanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1021/jm300214e

Reference yield:

: 897767-45-2
methyl N-(4-fluoro)benzyl-4H-thieno[3,2-b]pyrrole carboxylate

: 1047023-77-7
ethyl 1-(4-(4-fluorobenzyl)-4H-thieno[3,2-b]pyrrole-5-carbonyl)-piperidine-4-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium hydroxide / ethanol; water / 16 h / 40 °C

2.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / dichloromethane / 0.5 h / 20 °C

2.2: 16 h / 20 °C

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; potassium hydroxide; In ethanol; dichloromethane; water;
DOI:10.1021/jm300214e