N³-{amino[3-(trifluoromethyl)-phenyl]acetyl}-beta-alaninamide hydrochloride

Base Information

Chemical Name:N³-{amino[3-(trifluoromethyl)-phenyl]acetyl}-beta-alaninamide hydrochloride
CAS No.:1366063-22-0
Molecular Formula:C₁₂H₁₄F₃N₃O₂*ClH
Molecular Weight:325.718
Hs Code.:

N<sup>3</sup>-{amino[3-(trifluoromethyl)-phenyl]acetyl}-beta-alaninamide hydrochloride

Synonyms:N³-{amino[3-(trifluoromethyl)-phenyl]acetyl}-beta-alaninamide hydrochloride

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Chemical Property of N³-{amino[3-(trifluoromethyl)-phenyl]acetyl}-beta-alaninamide hydrochloride

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Technology Process of N³-{amino[3-(trifluoromethyl)-phenyl]acetyl}-beta-alaninamide hydrochloride

There total 3 articles about N³-{amino[3-(trifluoromethyl)-phenyl]acetyl}-beta-alaninamide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 1366063-65-1
tert-butyl {2-[(3-amino-3-oxopropyl)amino]-2-oxo-1-[3-(trifluoromethyl)phenyl]ethyl}carbamate

: 1366063-22-0
N³-{amino[3-(trifluoromethyl)-phenyl]acetyl}-beta-alaninamide hydrochloride

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; dichloromethane; at 20 ℃;

Reference yield:

: 146621-92-3
2-{[(tert-butoxy)carbonyl]amino}-2-[3-(trifluoromethyl)phenyl]acetic acid

: 1366063-22-0
N³-{amino[3-(trifluoromethyl)-phenyl]acetyl}-beta-alaninamide hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 0.5 h / 20 °C

1.2: 1 h / 20 °C

2.1: stationary phase Daicel Chiralpak AD-H, 10 nm, column: 250 mm×20 mm / 2-Methylpentane; isopropyl alcohol / Resolution of racemate

3.1: hydrogenchloride / 1,4-dioxane; dichloromethane / 20 °C

With hydrogenchloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In 1,4-dioxane; 2-Methylpentane; dichloromethane; N,N-dimethyl-formamide; isopropyl alcohol;

Reference yield:

: 1366063-59-3
tert-butyl {2-[(3-amino-3-oxopropyl)amino]-2-oxo-1-[3-(trifluoromethyl)phenyl]ethyl}carbamate

: 1366063-22-0
N³-{amino[3-(trifluoromethyl)-phenyl]acetyl}-beta-alaninamide hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1: stationary phase Daicel Chiralpak AD-H, 10 nm, column: 250 mm×20 mm / 2-Methylpentane; isopropyl alcohol / Resolution of racemate

2: hydrogenchloride / 1,4-dioxane; dichloromethane / 20 °C

With hydrogenchloride; In 1,4-dioxane; 2-Methylpentane; dichloromethane; isopropyl alcohol;