N-tert-butyloxycarbonylphenylalanine 3,4'-O-isopropylidene-5'-pyridoxyl ester

Base Information

Chemical Name:N-tert-butyloxycarbonylphenylalanine 3,4'-O-isopropylidene-5'-pyridoxyl ester
CAS No.:259106-70-2
Molecular Formula:C₂₅H₃₂N₂O₆
Molecular Weight:456.539
Hs Code.:

Synonyms:N-tert-butyloxycarbonylphenylalanine 3,4'-O-isopropylidene-5'-pyridoxyl ester

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Chemical Property of N-tert-butyloxycarbonylphenylalanine 3,4'-O-isopropylidene-5'-pyridoxyl ester

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Technology Process of N-tert-butyloxycarbonylphenylalanine 3,4'-O-isopropylidene-5'-pyridoxyl ester

There total 2 articles about N-tert-butyloxycarbonylphenylalanine 3,4'-O-isopropylidene-5'-pyridoxyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 1136-52-3
(2,2,8-trimethyl-4H-[1,3]dioxino[4,5-c]pyridin-5-yl)methanol

: 13734-34-4
N-tert-butoxycarbonyl-L-phenylalanine

: 259106-70-2
N-tert-butyloxycarbonylphenylalanine 3,4'-O-isopropylidene-5'-pyridoxyl ester

Guidance literature:: With dmap; dicyclohexyl-carbodiimide; In chloroform; at 20 ℃;

Reference yield:

: 58-56-0
pyridoxal hydrochloride

: 259106-70-2
N-tert-butyloxycarbonylphenylalanine 3,4'-O-isopropylidene-5'-pyridoxyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 91 percent / thionyl chloride / CHCl₃ / 6 h / 20 °C

2: 92 percent / DCC; DMAP / CHCl₃ / 20 °C

With dmap; thionyl chloride; dicyclohexyl-carbodiimide; In chloroform; 1: ketalization / 2: Esterification;

Reference yield:

: 259106-70-2
N-tert-butyloxycarbonylphenylalanine 3,4'-O-isopropylidene-5'-pyridoxyl ester

: 59880-97-6
formyl-methionyl-leucyl-phenylalanine

Guidance literature:: Multi-step reaction with 7 steps

1: TFA; acetone

2: 96 percent / Et₃N / 18 h / 20 °C

3: TFA; acetone

4: 95 percent / Et₃N / 18 h / 20 °C

5: aq. HCl; acetone / dioxane

6: 95 percent / HCOONa; Ac₂O / 1.33 h / 0 - 20 °C

7: 95 percent / aq. NaOH / methanol / 0.33 h / 20 °C

With hydrogenchloride; sodium hydroxide; sodium formate; acetic anhydride; triethylamine; acetone; trifluoroacetic acid; In 1,4-dioxane; methanol; 1: Elimination / 2: Condensation / 3: Elimination / 4: Condensation / 5: Hydrolysis / 6: Formylation / 7: Hydrolysis;
DOI:10.1007/BF02759163