imidazole-1-carboxylic acid [4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-methyl-amide

Base Information

• Chemical Name: imidazole-1-carboxylic acid [4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-methyl-amide
• CAS No.: 872168-52-0
• Molecular Formula: C₁₇H₂₅N₃O₂Si
• Molecular Weight: 331.49
• Mol file: 872168-52-0.mol

Synonyms:imidazole-1-carboxylic acid [4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-methyl-amide

Chemical Property of imidazole-1-carboxylic acid [4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-methyl-amide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of imidazole-1-carboxylic acid [4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-methyl-amide

There total 3 articles about imidazole-1-carboxylic acid [4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-methyl-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

4-[(tert-butyldimethylsilyl)oxy]-N-methylaniline (90446-71-2) + 1,1'-carbonyldiimidazole (530-62-1) → imidazole-1-carboxylic acid [4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-methyl-amide (872168-52-0)

Guidance literature:

In tetrahydrofuran; at 20 ℃;

DOI:10.1016/j.tetlet.2005.10.005

Reference yield:

4-(methylamino)phenol sulphate (55-55-0,1936-57-8) → imidazole-1-carboxylic acid [4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-methyl-amide (872168-52-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 97 percent / NaH / tetrahydrofuran / -78 °C

2: 91 percent / tetrahydrofuran / 20 °C

With sodium hydride; In tetrahydrofuran;

DOI:10.1016/j.tetlet.2005.10.005

Reference yield:

tert-butyldimethylsilyl chloride (18162-48-6) → imidazole-1-carboxylic acid [4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-methyl-amide (872168-52-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 97 percent / NaH / tetrahydrofuran / -78 °C

2: 91 percent / tetrahydrofuran / 20 °C

With sodium hydride; In tetrahydrofuran;

DOI:10.1016/j.tetlet.2005.10.005

upstream raw materials:

4-[(tert-butyldimethylsilyl)oxy]-N-methylaniline

1,1'-carbonyldiimidazole

4-(methylamino)phenol sulphate

tert-butyldimethylsilyl chloride

Downstream raw materials:

3-hydroxy-pyrrolidine-1-carboxylic acid [4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-methyl-amide