methyl 5-(benzyloxy)-2-(4-fluorophenyl)-6-(N-methylmethylsulfonamido)pyrazolo[1,5-a]pyridine-3-carboxylate

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Chemical Name:methyl 5-(benzyloxy)-2-(4-fluorophenyl)-6-(N-methylmethylsulfonamido)pyrazolo[1,5-a]pyridine-3-carboxylate
CAS No.:1621705-62-1
Molecular Formula:C₂₄H₂₂FN₃O₅S
Molecular Weight:483.52
Hs Code.:

Synonyms:methyl 5-(benzyloxy)-2-(4-fluorophenyl)-6-(N-methylmethylsulfonamido)pyrazolo[1,5-a]pyridine-3-carboxylate

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Chemical Property of methyl 5-(benzyloxy)-2-(4-fluorophenyl)-6-(N-methylmethylsulfonamido)pyrazolo[1,5-a]pyridine-3-carboxylate

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Technology Process of methyl 5-(benzyloxy)-2-(4-fluorophenyl)-6-(N-methylmethylsulfonamido)pyrazolo[1,5-a]pyridine-3-carboxylate

There total 6 articles about methyl 5-(benzyloxy)-2-(4-fluorophenyl)-6-(N-methylmethylsulfonamido)pyrazolo[1,5-a]pyridine-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 24.0%

: 1621705-61-0
N-(4-(benzyloxy)pyridin-3-yl)-N-methylmethanesulfonamide

: 42122-44-1
methyl 3-(4-fluorophenyl)propiolate

: 1621705-62-1
methyl 5-(benzyloxy)-2-(4-fluorophenyl)-6-(N-methylmethylsulfonamido)pyrazolo[1,5-a]pyridine-3-carboxylate

Guidance literature:: N-(4-(benzyloxy)pyridin-3-yl)-N-methylmethanesulfonamide; With mesitylenesulfonylhydroxylamine; In dichloromethane; at 0 - 20 ℃; for 2h; Inert atmosphere;

methyl 3-(4-fluorophenyl)propiolate; With potassium carbonate; In N,N-dimethyl-formamide; at 0 - 20 ℃; Inert atmosphere;

Reference yield:

: 13091-23-1
4-chloro-3-nitropyridine

: 1621705-62-1
methyl 5-(benzyloxy)-2-(4-fluorophenyl)-6-(N-methylmethylsulfonamido)pyrazolo[1,5-a]pyridine-3-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: Tris(3,6-dioxaheptyl)amine; potassium carbonate; potassium hydroxide / toluene / 2 h / 0 - 20 °C

2.1: ammonium chloride; iron / methanol; tetrahydrofuran; water / 3 h / Reflux

3.1: triethylamine / dichloromethane / 0 - 20 °C

3.2: 4 h / 20 °C

4.1: potassium carbonate / N,N-dimethyl-formamide / 1 h / 0 °C / Inert atmosphere

5.1: mesitylenesulfonylhydroxylamine / dichloromethane / 2 h / 0 - 20 °C / Inert atmosphere

5.2: 0 - 20 °C / Inert atmosphere

With Tris(3,6-dioxaheptyl)amine; mesitylenesulfonylhydroxylamine; iron; potassium carbonate; ammonium chloride; triethylamine; potassium hydroxide; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide; toluene;

Reference yield:

: 100-51-6,185532-71-2
benzyl alcohol

: 1621705-62-1
methyl 5-(benzyloxy)-2-(4-fluorophenyl)-6-(N-methylmethylsulfonamido)pyrazolo[1,5-a]pyridine-3-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: Tris(3,6-dioxaheptyl)amine; potassium carbonate; potassium hydroxide / toluene / 2 h / 0 - 20 °C

2.1: ammonium chloride; iron / methanol; tetrahydrofuran; water / 3 h / Reflux

3.1: triethylamine / dichloromethane / 0 - 20 °C

3.2: 4 h / 20 °C

4.1: potassium carbonate / N,N-dimethyl-formamide / 1 h / 0 °C / Inert atmosphere

5.1: mesitylenesulfonylhydroxylamine / dichloromethane / 2 h / 0 - 20 °C / Inert atmosphere

5.2: 0 - 20 °C / Inert atmosphere

With Tris(3,6-dioxaheptyl)amine; mesitylenesulfonylhydroxylamine; iron; potassium carbonate; ammonium chloride; triethylamine; potassium hydroxide; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide; toluene;