4-{2-[(1S,2S,3R,5S,6R)-2-Acetoxy-3,5-bis-benzyloxycarbonylamino-6-((2S,3R,4R,5S,6R)-4,5-diacetoxy-6-acetoxymethyl-3-benzyloxycarbonylamino-tetrahydro-pyran-2-yloxy)-cyclohexyloxy]-ethyl}-piperazine-1-carboxylic acid benzyl ester

Base Information

Chemical Name:4-{2-[(1S,2S,3R,5S,6R)-2-Acetoxy-3,5-bis-benzyloxycarbonylamino-6-((2S,3R,4R,5S,6R)-4,5-diacetoxy-6-acetoxymethyl-3-benzyloxycarbonylamino-tetrahydro-pyran-2-yloxy)-cyclohexyloxy]-ethyl}-piperazine-1-carboxylic acid benzyl ester
CAS No.:344779-94-8
Molecular Formula:C₅₈H₆₉N₅O₁₉
Molecular Weight:1140.21
Hs Code.:

4-{2-[(1S,2S,3R,5S,6R)-2-Acetoxy-3,5-bis-benzyloxycarbonylamino-6-((2S,3R,4R,5S,6R)-4,5-diacetoxy-6-acetoxymethyl-3-benzyloxycarbonylamino-tetrahydro-pyran-2-yloxy)-cyclohexyloxy]-ethyl}-piperazine-1-carboxylic acid benzyl ester

Synonyms:4-{2-[(1S,2S,3R,5S,6R)-2-Acetoxy-3,5-bis-benzyloxycarbonylamino-6-((2S,3R,4R,5S,6R)-4,5-diacetoxy-6-acetoxymethyl-3-benzyloxycarbonylamino-tetrahydro-pyran-2-yloxy)-cyclohexyloxy]-ethyl}-piperazine-1-carboxylic acid benzyl ester

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Chemical Property of 4-{2-[(1S,2S,3R,5S,6R)-2-Acetoxy-3,5-bis-benzyloxycarbonylamino-6-((2S,3R,4R,5S,6R)-4,5-diacetoxy-6-acetoxymethyl-3-benzyloxycarbonylamino-tetrahydro-pyran-2-yloxy)-cyclohexyloxy]-ethyl}-piperazine-1-carboxylic acid benzyl ester

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Technology Process of 4-{2-[(1S,2S,3R,5S,6R)-2-Acetoxy-3,5-bis-benzyloxycarbonylamino-6-((2S,3R,4R,5S,6R)-4,5-diacetoxy-6-acetoxymethyl-3-benzyloxycarbonylamino-tetrahydro-pyran-2-yloxy)-cyclohexyloxy]-ethyl}-piperazine-1-carboxylic acid benzyl ester

There total 4 articles about 4-{2-[(1S,2S,3R,5S,6R)-2-Acetoxy-3,5-bis-benzyloxycarbonylamino-6-((2S,3R,4R,5S,6R)-4,5-diacetoxy-6-acetoxymethyl-3-benzyloxycarbonylamino-tetrahydro-pyran-2-yloxy)-cyclohexyloxy]-ethyl}-piperazine-1-carboxylic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 31166-44-6
phenylmethyl 1-piperazinecarboxylate

: 344779-66-4
Acetic acid (1S,2S,3R,4S,6R)-4,6-bis-benzyloxycarbonylamino-3-((2S,3R,4R,5S,6R)-4,5-diacetoxy-6-acetoxymethyl-3-benzyloxycarbonylamino-tetrahydro-pyran-2-yloxy)-2-(2-oxo-ethoxy)-cyclohexyl ester

: 344779-94-8
4-{2-[(1S,2S,3R,5S,6R)-2-Acetoxy-3,5-bis-benzyloxycarbonylamino-6-((2S,3R,4R,5S,6R)-4,5-diacetoxy-6-acetoxymethyl-3-benzyloxycarbonylamino-tetrahydro-pyran-2-yloxy)-cyclohexyloxy]-ethyl}-piperazine-1-carboxylic acid benzyl ester

Guidance literature:: With sodium cyanoborohydride; In tetrahydrofuran; methanol; acetic acid; at 20 ℃;
DOI:10.1016/S0040-4020(01)00194-6

Reference yield:

: 23600-10-4
[(1R,2S,3R,4R,5S)-5-Benzyloxycarbonylamino-4-((2S,3R,4R,5S,6R)-3-benzyloxycarbonylamino-4,5-dihydroxy-6-hydroxymethyl-tetrahydro-pyran-2-yloxy)-2,3-dihydroxy-cyclohexyl]-carbamic acid benzyl ester

: 344779-94-8
4-{2-[(1S,2S,3R,5S,6R)-2-Acetoxy-3,5-bis-benzyloxycarbonylamino-6-((2S,3R,4R,5S,6R)-4,5-diacetoxy-6-acetoxymethyl-3-benzyloxycarbonylamino-tetrahydro-pyran-2-yloxy)-cyclohexyloxy]-ethyl}-piperazine-1-carboxylic acid benzyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: 46 percent / pyridine / dimethylformamide

2.1: 43 percent / tetrabutylammonium isodide; LiHMDS / dimethylformamide / 1.25 h / 20 °C

3.1: O₃ / CH₂Cl₂ / -78 °C

3.2: 84 percent / PPh₃ / CH₂Cl₂ / -78 - 20 °C

4.1: 94 percent / NaBH₃CN / methanol; acetic acid; tetrahydrofuran / 20 °C

With pyridine; tetra-(n-butyl)ammonium iodide; sodium cyanoborohydride; ozone; lithium hexamethyldisilazane; In tetrahydrofuran; methanol; dichloromethane; acetic acid; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4020(01)00194-6

Reference yield:

: 344779-64-2
Acetic acid (2R,3S,4R,5R,6S)-3-acetoxy-6-((1R,2S,3S,4R,6S)-3-acetoxy-4,6-bis-benzyloxycarbonylamino-2-hydroxy-cyclohexyloxy)-2-acetoxymethyl-5-benzyloxycarbonylamino-tetrahydro-pyran-4-yl ester

: 344779-94-8
4-{2-[(1S,2S,3R,5S,6R)-2-Acetoxy-3,5-bis-benzyloxycarbonylamino-6-((2S,3R,4R,5S,6R)-4,5-diacetoxy-6-acetoxymethyl-3-benzyloxycarbonylamino-tetrahydro-pyran-2-yloxy)-cyclohexyloxy]-ethyl}-piperazine-1-carboxylic acid benzyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: 43 percent / tetrabutylammonium isodide; LiHMDS / dimethylformamide / 1.25 h / 20 °C

2.1: O₃ / CH₂Cl₂ / -78 °C

2.2: 84 percent / PPh₃ / CH₂Cl₂ / -78 - 20 °C

3.1: 94 percent / NaBH₃CN / methanol; acetic acid; tetrahydrofuran / 20 °C

With tetra-(n-butyl)ammonium iodide; sodium cyanoborohydride; ozone; lithium hexamethyldisilazane; In tetrahydrofuran; methanol; dichloromethane; acetic acid; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4020(01)00194-6