N-((5-(4-(benzyloxy)phenyl)-1,3,4-oxadiazol-2-yl)methyl)-7-(3-fluorophenoxy)-2-hydroxyheptanamide

Base Information

Chemical Name:N-((5-(4-(benzyloxy)phenyl)-1,3,4-oxadiazol-2-yl)methyl)-7-(3-fluorophenoxy)-2-hydroxyheptanamide
CAS No.:1369796-81-5
Molecular Formula:C₂₉H₃₀FN₃O₅
Molecular Weight:519.573
Hs Code.:

Synonyms:N-((5-(4-(benzyloxy)phenyl)-1,3,4-oxadiazol-2-yl)methyl)-7-(3-fluorophenoxy)-2-hydroxyheptanamide

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Chemical Property of N-((5-(4-(benzyloxy)phenyl)-1,3,4-oxadiazol-2-yl)methyl)-7-(3-fluorophenoxy)-2-hydroxyheptanamide

Chemical Property:

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Technology Process of N-((5-(4-(benzyloxy)phenyl)-1,3,4-oxadiazol-2-yl)methyl)-7-(3-fluorophenoxy)-2-hydroxyheptanamide

There total 6 articles about N-((5-(4-(benzyloxy)phenyl)-1,3,4-oxadiazol-2-yl)methyl)-7-(3-fluorophenoxy)-2-hydroxyheptanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1369796-80-4
(5-(4-(benzyloxy)phenyl)-1,3,4-oxadiazol-2-yl)methanamine

: 1369796-78-0
7-(3-fluorophenoxy)-2-hydroxyheptanoic acid

: 1369796-81-5
N-((5-(4-(benzyloxy)phenyl)-1,3,4-oxadiazol-2-yl)methyl)-7-(3-fluorophenoxy)-2-hydroxyheptanamide

Guidance literature:: With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide;

Reference yield:

: 372-20-3
3-fluorophenol

: 1369796-81-5
N-((5-(4-(benzyloxy)phenyl)-1,3,4-oxadiazol-2-yl)methyl)-7-(3-fluorophenoxy)-2-hydroxyheptanamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium hydroxide / water / 3 h / Reflux

2.1: Dess-Martin periodane / 2.5 h / 20 °C / Cooling with ice

3.1: ethyl acetate; water / 20 h

4.1: hydrogenchloride / 18 h / -78 - -10 °C

5.1: water; lithium hydroxide / 1,4-dioxane / 4 h

5.2: pH ~ 3

6.1: N-ethyl-N,N-diisopropylamine; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide / N,N-dimethyl-formamide

With hydrogenchloride; water; benzotriazol-1-ol; Dess-Martin periodane; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; N-ethyl-N,N-diisopropylamine; sodium hydroxide; lithium hydroxide; In 1,4-dioxane; water; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 1369796-75-7
6-(3-fluorophenoxy)hexanal

: 1369796-81-5
N-((5-(4-(benzyloxy)phenyl)-1,3,4-oxadiazol-2-yl)methyl)-7-(3-fluorophenoxy)-2-hydroxyheptanamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: ethyl acetate; water / 20 h

2.1: hydrogenchloride / 18 h / -78 - -10 °C

3.1: water; lithium hydroxide / 1,4-dioxane / 4 h

3.2: pH ~ 3

4.1: N-ethyl-N,N-diisopropylamine; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide / N,N-dimethyl-formamide

With hydrogenchloride; water; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; N-ethyl-N,N-diisopropylamine; lithium hydroxide; In 1,4-dioxane; water; ethyl acetate; N,N-dimethyl-formamide;