N-((5-(4-(benzyloxy)phenyl)-1,3,4-oxadiazol-2-yl)methyl)-7-(3-fluorophenoxy)-2-oxoheptanamide

Base Information

Chemical Name:N-((5-(4-(benzyloxy)phenyl)-1,3,4-oxadiazol-2-yl)methyl)-7-(3-fluorophenoxy)-2-oxoheptanamide
CAS No.:1369795-50-5
Molecular Formula:C₂₉H₂₈FN₃O₅
Molecular Weight:517.557
Hs Code.:

Synonyms:N-((5-(4-(benzyloxy)phenyl)-1,3,4-oxadiazol-2-yl)methyl)-7-(3-fluorophenoxy)-2-oxoheptanamide

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Chemical Property of N-((5-(4-(benzyloxy)phenyl)-1,3,4-oxadiazol-2-yl)methyl)-7-(3-fluorophenoxy)-2-oxoheptanamide

Chemical Property:

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Technology Process of N-((5-(4-(benzyloxy)phenyl)-1,3,4-oxadiazol-2-yl)methyl)-7-(3-fluorophenoxy)-2-oxoheptanamide

There total 8 articles about N-((5-(4-(benzyloxy)phenyl)-1,3,4-oxadiazol-2-yl)methyl)-7-(3-fluorophenoxy)-2-oxoheptanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1369796-81-5
N-((5-(4-(benzyloxy)phenyl)-1,3,4-oxadiazol-2-yl)methyl)-7-(3-fluorophenoxy)-2-hydroxyheptanamide

: 1369795-50-5
N-((5-(4-(benzyloxy)phenyl)-1,3,4-oxadiazol-2-yl)methyl)-7-(3-fluorophenoxy)-2-oxoheptanamide

Guidance literature:: With Dess-Martin periodane; In dichloromethane;

Reference yield:

: 372-20-3
3-fluorophenol

: 1369795-50-5
N-((5-(4-(benzyloxy)phenyl)-1,3,4-oxadiazol-2-yl)methyl)-7-(3-fluorophenoxy)-2-oxoheptanamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: sodium hydroxide / water / 3 h / Reflux

2.1: Dess-Martin periodane / 2.5 h / 20 °C / Cooling with ice

3.1: ethyl acetate; water / 20 h

4.1: hydrogenchloride / 18 h / -78 - -10 °C

5.1: water; lithium hydroxide / 1,4-dioxane / 4 h

5.2: pH ~ 3

6.1: N-ethyl-N,N-diisopropylamine; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide / N,N-dimethyl-formamide

7.1: Dess-Martin periodane / dichloromethane

With hydrogenchloride; water; benzotriazol-1-ol; Dess-Martin periodane; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; N-ethyl-N,N-diisopropylamine; sodium hydroxide; lithium hydroxide; In 1,4-dioxane; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 1369796-74-6
6-(3-fluorophenoxy)hexan-1-ol

: 1369795-50-5
N-((5-(4-(benzyloxy)phenyl)-1,3,4-oxadiazol-2-yl)methyl)-7-(3-fluorophenoxy)-2-oxoheptanamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: Dess-Martin periodane / 2.5 h / 20 °C / Cooling with ice

2.1: ethyl acetate; water / 20 h

3.1: hydrogenchloride / 18 h / -78 - -10 °C

4.1: water; lithium hydroxide / 1,4-dioxane / 4 h

4.2: pH ~ 3

5.1: N-ethyl-N,N-diisopropylamine; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide / N,N-dimethyl-formamide

6.1: Dess-Martin periodane / dichloromethane

With hydrogenchloride; water; benzotriazol-1-ol; Dess-Martin periodane; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; N-ethyl-N,N-diisopropylamine; lithium hydroxide; In 1,4-dioxane; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide;